本项目是在前期交叉偶联反应系列研究工作的基础上，拟通过过渡金属催化的烯丙基化及多重烯炔反应构筑几种多烯或环状复杂体系化合物，研究C-X键与C-H键活化，新C-C键的形成偶联反应的变化规律，探索一锅方法合成三烯或多环化合物的新方法及其适应性,探索不同催化剂或催化体系对反应的影响、开发出性能优良的适用于合成复杂有机化合物的催化剂或催化体系。同时深入探索反应底物结构对形成产物结构影响因素及规律性，探索电子、立体因素对Domino反应的影响，必将为tandem sequence串联反应的机制研究及合成具有三烯或多环化合物的药物分子设计以及利用不对称的Domino反应专一性地构建一些特定类型的天然产物骨架分子开辟崭新的途径。因此项目研究具有一定的理论意义和潜在应用价值。

The project is based on the prophase series of work about cross-coupling reaction.We will develop a transition metal-catalyzed allylation and multienynes via sequential domino reaction to construct sevaral complex system of polyenes or cyclic compounds. Study the rules of activation of C-X/C-H bond and the coupling reaction of the formation of new C-C bond. Research on the development of new method and adaptation of one-step synthesis trienes or polycyclic compounds. Exploring different catalyst/catalytic symtems to influence the reaction. Exploring high performance catalyst/catalytic symtem in relation to synthesis of complex organic compound. Meanwhile, the effective factors and the correlative regularity of what substrate structure influence on products strusture are seeken for. Exploring how some factors such as electronic effect and steric effect influence the domino reaction. The study of the reaction mechanism of tandem sequence reaction and synthesis of trienes and polycyclic compound provide new ways for molecular drug design and construction of natural product skeleton via specificity of asymmetric domino reaction.Therefore,this research has important theoretical significance and potential application value.