石榴皮为石榴科石榴属植物石榴 Punica granatum L.的干燥果皮，收载于2010版《中国药典》，用于治疗久泻，久痢，便血，脱肛，崩漏，带下，虫积腹痛。石榴皮中多酚及其主成分安石榴苷具有显著的抗氧化、抗菌及抗肿瘤活性，但安石榴苷口服吸收差，目前，对石榴皮多酚抗肿瘤有效部位及其主成分安石榴苷口服给药后，其在胃肠道的吸收和代谢特性尚不清楚。.在前期工作基础上，本课题以新疆酸石榴皮中提取分离的抗肿瘤多酚精制物及其主成分安石榴苷为研究对象，分别采用大鼠肠襻模型、Caco-2细胞模型、整体实验动物、肠道菌群体外代谢模型和肝微粒体代谢模型研究其在胃肠道的体内外吸收过程和体外代谢过程，为科学评价石榴皮多酚抗肿瘤有效部位口服给药的药用价值和体内抗肿瘤有效成分的确证提供药动学依据，在设计口服抗肿瘤新制剂时为提高生物利用度和临床疗效提供实验依据。

Pomegranate peel is the dry peel of Punica granatum L., which belongs to Punical plant in Punicaceae. It was collected in the Chinese Pharmacopoeia（2010 version）and used to treat chronic diarrhea, chronic dysentery, bloody diarrhea, prolapse of anus, uterine bleeding, abnormal vaginal discharge, abdominal pain parasitic. The polyphenolic compounds of pomegranate peel and its major components punicalagin have good antioxidant, antimicrobial and antitumor activity. The gastrointestinal absorption of punicalagin is low following oral administration. At present, the gastrointestinal absorption and metabolic characteristics of the anti-tumor effective fraction of polyphenol and punicalagin from the pomegranate peel by oral administration are still unclear. .Based on previous research results, the project will separate polyphenols extract and punicalagins, which have antitumor activity, from the peel of Punica granatum L. in xinjiang. The gastrointestinal absorption processes of them were systematically investigated based on the models of intestine loop, Caco-2 cell and whole animal. The metabolic processes of them were systematically investigated based on the intestinal flora metabolic model and rat liver microsomes metabolic model in vitro. It will provide pharmacokinetic basis for the scientific evaluation of the medicinal value of anti-tumor activity of the polyphenol extract from pomegranate peel by oral administration and determine antitumor component in vivo. It will also provide experimental basis for increasing the oral bioavailability and clinical effect when anti-tumor new drug was design in the future.