脂肪酸代谢在肿瘤侵袭转移中发挥重要作用。最新发现，同源盒基因PRRX1不仅是一种新的EMT转录因子，而且其负性调控PPARG2的信号通路在脂肪细胞脂肪酸代谢中发挥关键作用。基于此，课题组在前期研究基础上提出假设：PRRX1/PPARG2通过驱动口腔鳞癌脂肪酸代谢重编程，调控EMT和MET动态转换，促进不同阶段侵袭转移。拟从肿瘤脂肪酸代谢重编程与EMT可塑性关系新维度，以PRRX1/PPARG2信号通路为把手，研究和明确在PRRX1调控口腔鳞癌脂肪酸代谢重编程从而影响EMT可塑性中，两个亚型PRRX1a和PRRX1b是否发挥不同作用？是否可相互转换？PRRX1/PPARG2通路通过下游哪些脂肪酸代谢关键分子、酶和信号通路影响肿瘤脂肪酸代谢，影响哪些EMT通路，进而动态调控侵袭转移不同阶段EMT和MET转换，协调与整合口腔鳞癌侵袭转移全过程？结果将为靶向口腔鳞癌侵袭转移的精准治疗提供新思路。

Fatty acid metabolism reprogramming plays an important role in the invasion and metastasis of malignant tumors. Recently, PRRX1, one of homeobox genes, has been regarded to be an important transcription factor of EMT,but also it has been shown to mediate fat synthesis and fatty acid metabolism of adipocytes. Thus, based on our previous data of the relationship between EMT and the invasion and metastasis of oral squamous cell carcinoma (OSCC), we hypothesise that PRRX1/PPARG2 signaling pathway engages in EMT plasticity to contribute to the invasion and metastasis of OSCC through fatty acid metabolism reprogramming. From the new perspective of fatty acid metabolism reprogramming association with tumor EMT plasticity, this project will investigate the following questions: Whether can the balance between PRRX1 two isoforms (PRRX1a and PRRX1b) switch, and can the PRRX1 isoform switching play different roles during the PRRX1 regulating fatty acid metabolism reprogramming and EMT plasticity of OSCC? Which are the key genes,enzymes,proteins and signaling pathways during PRRX1/PPARG2 signaling pathway controlling fatty acid metabolism reprogramming in OSCC metastasis? How does fatty acid metabolism reprogramming dynamically engage in EMT plasticity to contribute to the invasion and metastasis of OSCC? The data of this project will have promising to yield a novel therapeutic strategy to the precision medicine for OSCC invasion and metastasis in the future.