塑料的大量生产和使用不可避免地导致海洋环境中塑料微粒的数量日益增多。这些塑料微粒将给海洋带来难以预料的环境效应和生态风险，已引起国际社会的高度关注。目前，塑料微粒对海洋生物及生态系统影响的研究正处于起步阶段，从分子水平探讨其毒性效应及评估其毒性风险的研究鲜有报道。本项目选择我国北方典型海湾——莱州湾作为研究区域，通过检测该海湾主要塑料微粒的丰度和分布，初步查明塑料微粒的污染程度；采用常规毒理学、转录组学及蛋白质组学等技术，查明典型塑料微粒对莱州湾代表性海洋生物不同生活史阶段的急性和慢性毒性效应，并从分子水平上解析其毒性作用机制；在此基础上，进一步探索典型塑料微粒与环境中其它污染物的联合毒性效应，全面评估其毒性作用机制。研究结果不仅有助于更准确地评价海洋塑料微粒污染的生态风险，还可为我国塑料污染的管理和相关政策的制定提供科学依据。

The number of microplastics will increase inevitably in marine environment due to large amount of production and usage of plastics. The microplastic which might cause unpredictable environmental effect and ecological risk has attracted high attention from international societies. Presently, the research on the impacts of microplastic on marine organisms and ecosystem is still at the initial stage, and the molecular mechanism of its toxic effect and the toxicological risk evaluation is rarely reported. In this project, we aim to investigate the abundance and distribution of major microplastics in Laizhou Bay to clarify their pollution status. The acute and chronic toxicity of typical microplastics on representative marine organism of different life history stages is studied by traditional toxicological, transcriptomic and proteomic methods. Additionally, the molecular toxic mechanism of microplastic on marine organism is discussed. On this basis, the combined toxicity of typical microplastics and other pollutants is studied so as to evaluate the toxicity of microplastic systematically. The results of this project will contribute to evaluate the ecological risk of microplastic more accurately, and provide scientific basis for plastic pollution management and relevant policy making.