近年来，尽管具有抑制神经内分泌系统激活的药物使用使慢性心力衰竭（chronic heart failure，CHF）患者的死亡率明显降低，但CHF患者的总体预后仍然欠佳。故寻找新的治疗方法是临床亟待解决的问题。目前，阻断心力衰竭心肌能量代谢重塑也是防止CHF过快发展、死亡率增加的预期治疗靶点。而早期心衰的能量代谢途径被推断和免疫炎症息息相关。胆碱能抗免疫炎症通路是一条迷走神经依赖的信号通路，它可以抑制免疫炎症细胞因子的释放。然而此通路对于CHF关键的心肌能量代谢重塑有何影响？是否在此通路上有关键点存在，可以作为将来选择性的靶点防治CHF？本实验通过对胆碱能抗免疫炎症通路的激活和抑制，了解对机体免疫炎症反应以及心肌能量代谢、细胞内信号转导系统JAK-STAT-SOCS各个关键点的影响。探讨治疗CHF的新途径。

It is known that chronic heart failure (CHF) is a major cause of cardiac deaths.Recently, the drug of inhibiting activation of neuroendocrine system has made the reduction in mortality among patients with chronic heart failure, but the overall of CHF patients remains poor prognosis. So looking for a new treatment is the clinical important problems need to be solved immediately. At present，blocking myocardial energy metabolic remodeling is the one of targets in preventing heart failure too fast development and increased mortality. It is speculated that energy metabolic pathways and immune inflammation are closely related in CHF. Cholinergic anti immune inflammatory pathway is a vagal rely signaling pathways, it can inhibit the immune inflammatory cytokines release. However, what is the effect of cholinergic anti immune inflammatory pathway to the myocardial energy metabolic remodeling in CHF patients? Whether there is a key point on this path, and can be used as a selective targets for prevention and control of CHF in the future? This experiment through the cholinergic anti immune activation and inhibition of inflammatory pathways, understanding effects of each key point of the immune inflammation and myocardial energy metabolism, cell signal transduction system JAK - STAT – SOCS. Exploring new ways for the treatment of CHF.