Renal Sympathetic Denervation Improves Outcomes in a Canine Myocardial Infarction Model
Renal Sympathetic Denervation Improves Outcomes in a Canine Myocardial Infarction Model
复制标题
肾交感神经去神经改善犬心肌梗死模型的结果
DOI：
10.12659/msm.914384
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yanmei Lu
中科院分区：
文献类型：
--
作者：
Buajieer;Xue Lou;Yinling Zhang;Huaxin Sun;Xianhui Zhou;Yaodong Li;Qi;Jianghua Zhang;B. Tang;Yanmei Lu
Background Myocardial infarction (MI) is the main cause of heart failure (HF), and sympathetic nerve activity is associated with prognosis chronic heart failure. Renal sympathetic denervation (RDN) is noted for its powerful effect on the inhibition of sympathetic nerve activity. This study investigated the effect of RDN on heart failure in dogs after myocardial infarction. Material/Methods The experimental animals were randomized into 2 groups: the MI group (n=12) and the sham operation group (n=6). In the MI group we established an MI model by permanently ligating the left anterior descending branch. After 4 weeks, the MI dogs were randomly divided into 2 groups: the MI+RDN group (MI+renal sympathetic denervation, n=6) and the simple MI group (n=6). Animals in the MI+RDN group underwent both surgical and chemical renal denervation. Results Compared with sham operation group, left ventricular fraction shortening (LVFS) and left ventricular ejection fraction (LVEF) were significantly reduced in the simple MI group, while the reduction was partly reversed in the MI+RDN group. RDN reduced sympathetic nerve activity and release of B-type natriuretic peptide (BNP) and Angiotensin II (AngII) in the MI+ RDN group but not in the simple MI group. Conclusions Canine renal sympathetic denervation prevents myocardial malignant remodeling by lowering the activity of the systemic sympathetic nerve and inhibiting renin-angiotensin-aldosterone system (RASS) activation, providing a new target and method for the treatment of heart failure.
影响因子：
24
作者：
Sharp, Thomas E., III;Polhemus, David J.;Goodchild, Traci T.
通讯作者：
Goodchild, Traci T.
影响因子：
37.8
作者：
Cao, JM;Fishbein, MC;Chen, LS
通讯作者：
Chen, LS
影响因子：
24
作者：
Polhemus, David J.;Trivedi, Rishi K.;Lefer, David J.
通讯作者：
Lefer, David J.