含有手性的四氢喹啉或手性苯并环庚胺结构单元不但构成了许多天然产物，而且也是许多具有生物活性的分子或相关药物分子的特征结构。发展有效的合成方法来构建新型的、结构多样化的手性四氢喹啉类和手性苯并环庚胺类化合物，是有机合成中一具有挑战性的课题。基于我们的研究基础，我们采用自行设计合成的具有多手性中心的手性二胺类配体及各种商业化易得的手性配体，和金属络合作为手性Lewis acids催化剂，用于分子内不对称串联1,5-氢迁移/环合反应的研究，合成结构多样化的手性四氢喹啉类和手性苯并环庚胺类化合物，并合成多种结构复杂的含有螺环结构的手性四氢喹啉类和手性苯并环庚胺类化合物。同时，考察各种因素对催化不对称反应的效率和立体选择性的影响，揭示其不对称催化的反应机理。此项目的开展不但可为不对称催化合成领域增加新颖的内容，而且可为高效合成结构多样化的四氢喹啉类和苯并环庚胺类提供新方法和新思路。

Chiral tetrahydroquinolines and chiral tetrahydro-benzo[b]azepines have emerged as attractive synthetic targets because of their prevalence in numerous natural products and significant biological activity compounds. Searching for creative strategies that could achieve high reactivity and stereoselectivity for the construction of structurally diverse tetrahydroquinolines and tetrahydro-benzo[b]azepines is still challenging and interesting, because it might be really applied not only to natural products synthesis but also to library synthesis in medicinal chemistry. Based on our previous studies, in this project, we plan to investigate diversely asymmetric intramolecular tandem 1,5-hydride transfer/ring closure reactions with some metal complexes, in situ generating from various chiral ligangs and metal salts, as chiral Lewis acids catalysts for the construction of structurally diverse tetrahydroquinoline and tetrahydro-benzo[b]azepine derivatives. Meanwhile, we also will systemically study various influence factors on the reactivity, diastereo- and enantioselectivity, as well as disclose the possible reaction mechanism. The realization of this project will provide a viable approach to synthesize optically active structurally diverse spirocycle oxindoles.