体重波动对不同乳腺癌风险人群相关肿瘤生物标志物影响的前瞻性研究

基于我国乳腺癌缺乏一级预防手段的情况，本课题拟研究体重波动对不同乳腺癌风险人群相关肿瘤生物标志物的影响，为我国开展以体重干预为手段的乳腺癌精准预防提供实证证据。本项目由3个部分构成：①构建风险等级模型，用于风险评估；②通过剂量-反应Meta分析，结合病例对照研究(150对)，筛选肥胖-乳腺癌病因链上的效应生物标志物；③开展体重控制前瞻性研究，基于风险评估等级+基线BMI水平选择4组(75人/组)研究对象，利用互联网+的模式开展个性化体重干预和日常随访(0/3/6/9/12月)，项目开展后0、6、12月采集研究对象5ml静脉血用于基因和标志物检测，此外，在项目开始和随访结束时对研究对象进行两次乳腺超声免费检查，最后应用SEM-GC方法探究体重波动对不同乳腺癌风险人群相关肿瘤生物标志物的影响。

Based on the condition of lack of primary prevention methods for breast cancer in our country, our project intends to investigate the influence of weight fluctuations on relevant tumor biomarkers in population with different levels of breast cancer risk, and provide empirical evidence for conducting weight control intervention based accurate prevention of breast cancer in China. This project is composed of three parts: (1) Establish a risk level model for risk assessment; (2) Screen obesity-effector biomarkers on the causal link of breast cancer using dose-response meta-analysis combined with a case-control study (150 pairs) ; (3) Carry out a prospective study. We will divide the population into 4 groups (75 per group) based on the risk levels and baseline BMI. Then daily follow-up, at the 0/3/6/9/12 months follow-up, and individualized weight control will be performed via the Internet+ model. At the 0/6/12 months follow-up, 5ml of whole blood samples will be collected for biomarkers and susceptibility gene testing. Besides, two ultrasound examinations of breast will be performed at the beginning of the project and the end of the follow-up. At last, we will use SEM-GC method to explore the impact of weight fluctuation on relevant tumor biomarkers in population with different levels of breast cancer risk.