Association of C‐reactive protein with breast cancer is stronger for the potentially obese women: A Chinese case‐control study and meta‐analysis of 19 studies
Association of C‐reactive protein with breast cancer is stronger for the potentially obese women: A Chinese case‐control study and meta‐analysis of 19 studies
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对于潜在肥胖女性来说，C反应蛋白与乳腺癌的关联性更强：一项中国病例对照研究和 19 项研究的荟萃分析
DOI：
10.1111/jebm.12455
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发表时间：
2021-10
影响因子：
--
通讯作者：
Jiayuan Li
中科院分区：
文献类型：
--
作者：
Xiaofan Zhang;Mengyuan Wang;Yu Hao;Bin Xu;Lulu Tian;Yunqi Miao;Long Cheng;Jiayuan Li
亲爱的编辑，乳腺癌（BC）是全球最常见的癌症，据国际癌症研究机构世界癌症报告1估计，2020年新诊断病例约为226万例。随着对BC研究的深入，慢性炎症以及与肥胖的复杂关联对BC风险的作用仍有待研究。然而，炎症的明确作用尚不明确。2 C反应蛋白（CRP）是慢性炎症的敏感和非特异性标志物。Meta分析检查了15项队列和病例对照研究中的5286例病例，发现CRP每自然对数单位变化的风险增加16%。当按绝经状态分层时，仅在绝经后妇女中风险增加显著。然而，在这项荟萃分析中，很少有研究是绝经前妇女，目前还不清楚CRP和BC之间的具体联系是否会随着绝经状态而变化。此外，有证据表明，CRP对乳腺癌发生的影响在不同体型的个体中可能不同，超重和肥胖女性的风险估计更高。4 -6肥胖，如身体质量指数（BMI）的人体测量所反映的，是绝经后BC的既定因素，与CRP的循环水平密切相关。7因此，为了解释CRP和BC风险之间的更多联系以及肥胖相关测量在两者之间的调节作用，我们通过荟萃分析19项研究的线性和非线性剂量反应估计值，在现有证据的背景下进行了研究（补充材料1和3）。与最近的荟萃分析相比，本次荟萃分析增加了35项研究（包括1项更新的，3项最新出版物和我们的病例对照研究），50，774例受试者（涉及2412例病例）（图S2）。我们在中国西南地区对312例病例和312名年龄匹配的对照进行了研究（补充材料2）。同时采集空腹血浆样本和人体测量参数。采用多因素logistic回归分析调整主要混杂因素以获得优势比。此外，分层分析的月经状态和肥胖的指标，无论是体重指数或腰臀比，随后进行。检索至2020年1月，但没有符合条件的文章被添加到现有的库中。我们拟合了固定效应和随机效应模型，但随机效应优先解释异质性。
Dear Editor, Breast cancer (BC) is the commonest cancerworldwide,with anestimated 2.26 million newly diagnosed cases in 2020 according to the International Agency for Research on CancerWorld Cancer Reports.1 With the in-depth study of BC, the role of chronic inflammation and intricate association with obesity for the risk of BC remains to be studied. However, a clear role of inflammation is less well defined.2 Creactive protein (CRP) is a sensitive and nonspecific marker of chronic inflammation. Themeta-analysis examined 15 cohort and case-control studies in 5286 cases,3 finding that risk increased by 16% for per natural-log unit change in CRP. When stratified by menopausal status, the risk increase was significant only in postmenopausal women. However, few studies in this meta-analysis were of premenopausal women, and it is still unclear whether the specific link between CRP and BC would vary with menopausal status. Also, there was evidence to suggest that the impact of CRP on breast carcinogenesis may vary among individuals of different body sizes, with stronger risk estimates in overweight and obese women.4–6 Obesity, as reflected by anthropometric measurement of body mass index (BMI), is an established contributor for postmenopausal BC and closely correlates with circulating levels of CRP.7 Therefore, to explain more association between CRP and BC risk and the regulatory role of obesity-related measurements in between, we studied in the context of the available evidence by meta-analyzing linear and nonlinear dose–response estimates on 19 studies (Supplementarymaterial 1 and3). Comparedwith the recentmeta-analysis,3 5 studies (including 1updated, 3 latest publications, and our case-control study) of 50,774 participants (involving 2412 cases) were added in this meta-analysis (Figure S2). We conducted a study on 312 cases and 312 age-matched controls in southwest China (Supplement material 2). Fasting plasma samples and anthropometric parameters were collected simultaneously. Multiple logistic regression adjustedmajor confounders was used to obtain the odds ratios. Besides, stratified analyses both by menstrual status and indicators of obesity, either BMI or WHR, were subsequently performed. Re-search to January 2020, but no eligible article has been added to the existing library.We fitted both fixed-effects and random-effects models, but random-effects took precedence for explaining the hetero-
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影响因子：
9.8
作者：
Anty, Rodolphe;Bekri, Soumeya;Gual, Philippe
通讯作者：
Gual, Philippe
影响因子：
2.3
作者：
Dossus, Laure;Jimenez-Corona, Aida;Mesrine, Sylvie
通讯作者：
Mesrine, Sylvie
影响因子：
3.9
作者：
Divella R;De Luca R;Abbate I;Naglieri E;Daniele A
通讯作者：
Daniele A
在两项前瞻性研究和一项荟萃分析中，血浆C反应蛋白和乳腺癌的风险。
DOI：
10.1158/1055-9965.epi-15-0187
发表时间：
2015-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Wang J;Lee IM;Tworoger SS;Buring JE;Ridker PM;Rosner B;Hankinson SE
通讯作者：
Hankinson SE
影响因子：
120.7
作者：
Visser, M;Bouter, LM;Harris, TB
通讯作者：
Harris, TB