手性金属有机骨架材料用于手性农药富集及分离的研究

手性分离一直是分离科学中的一个难点，无论是色谱分离还是固相微萃取分离富集技术，其核心都是设计和制备具有高选择性的手性固定相。为了发展高手性分离能力且易于制备的新型手性固定相材料，本项目拟从手性金属有机骨架材料合成和手性色谱柱制备两方面着手创新研究。包括发展具有手性拆分性能的新型手性金属有机骨架材料；制备基于手性金属有机骨架材料，具有高选择性、强分离能力的手性气相色谱柱，以及制备具有强富集能力、高选择性的气相手性固相微萃取柱，以实现在最优气相色谱条件下的手性农药的选择性富集以及有效的分离。通过本项目实施，不仅能制备一系列新型具有手性特性的孔洞金属有机骨架材料，提供手性金属有机骨架材料制备的理论与方法指导，而且通过将手性金属有机骨架材料作为色谱固定相和SPME涂层，可以实现对手性农药的富集与分离检测，为手性物质的富集、拆分提供有意义的理论依据和技术支持。

The study of chiral resolution has become a difficult and hot topic in analysis science, its core is the design and fabrication of chiral stationary phase with high selectivity. For the development of novel chiral stationary with high selectivity, high separation capability and easy preparation, the key points of this research will be focused on the synthesis of chiral metal organic frameworks and the fabrication of chiral chromatographic column, including the development of chiral metal organic frameworks with chiral resolution capability and the preparation of chiral capillary gas chromatography column with high selectivity and high separation capability. The preparation of SPME chiral column with high enrichment capacity is also studied. Therefore the selective enrichment and separation of chiral molecules can be achieved in gas chromatography. The implementation of this project will make it possible to fabricate a series of novel homochiral metal organic frameworks, which provides the theory basis and the method instruction for the fabrication of homochiral metal organic frameworks. By applying the homochiral MOFs as chromatographic stationary phase and SPME coating, a new method for enrichment and separation of chiral pesticide was achieved,which provides meaningful theory basis and technical support for chiral resolution.