炔烃作为一类廉价易得的化学原料，是一种非常有用的有机合成砌块，在有机合成中应用广泛。随着金属催化效率和选择性的提高，炔烃经由金属卡宾过程的催化反应得到了很大程度的关注和发展。基于我们前期金属卡宾/炔烃复分解串联反应构建杂多环化合物的研究基础，本项目拟开展以稳定易得的炔烃作为金属卡宾前体，注重对反应催化和成键过程的创新：通过催化剂选择性活化炔烃并与重氮基团亲核性的碳加成，释放一份子氮气，实现形式上的卡宾/炔烃复分解反应直接构建乙烯基金属卡宾中间体，避免直接催化重氮基团产生的副反应，从而发展高效的炔烃官能团化新反应。主要研究内容包括基于形式上卡宾/炔烃复分解过程的新串联反应研究，重氮-炔烃催化加成反应中的选择性控制研究，以及炔烃作为卡宾前体的多组分新反应探索三个方面。研究工作不仅可以丰富金属卡宾化学，开发新型的卡宾前体以及卡宾产生途径，发现新的反应；也将为炔烃官能团化提供高效、绿色的新方法。

Alkyne, as an inexpensive and readily available chemical material, is a very useful synthon and has been widely used in organic synthesis. With the improvement of metal catalytic efficiency and selectivity, the catalytic reactions of alkynes through the metal carbene intermediate have been paid much attention and been well developed. Based on our previous studies on carbene/alkyne metathesis cascade reaction for the construction polycyclic heterocycles, this project intends to use relatively stable and readily accessible alkyne as metal carbene precursor, and focuses on the innovation in catalytic model and bond-formation sequences. The process is initiated by selective catalytic activation of the alkyne species followed the nucleophilic addition with the "C" of the diazo group, releasing a molecule of nitrogen simultaneously, and realization a formal carbene/alkyne metathesis process for the construction of the vinyl metal carbene intermediate. By avoiding the directly catalytic decomposition of diazo group and the following side reaction(s), novel and efficient transformations for the alkyne functionalization could be enabled. The main research contents include the development of novel cascade reactions based on the formal carbene/alkyne metathesis (CAM) chemistry, selectivity control in diazo-alkyne catalytic addition reactions, and the exploration of novel multi-component reactions with alkynes as carbene precursors. The proposed research project will not only enrich the metal carbene chemistry effectively, but also reveal new types of carbene precursors and disclose the methods for its generation, and finally will enable the development of novel metal carbene reactions. Moreover, it will provide a novel method for the alkyne functionalization efficiently and eco-friendly.