疼痛严重影响着人们的身体健康,而大多数镇痛药具有耐药性且副作用大，目前尚缺乏有效的治疗手段，因此亟需开发有效且安全的新型镇痛剂。结合前期的工作基础，本项目拟以多巴胺受体D2为靶点，整合先进的分离纯化技术、细胞筛选模型与动物模型，从传统中药延胡索中寻找具有疗效好、毒副作用小的镇痛活性成分。本项目的研究将为解读镇痛中药的作用机理提供理论依据和物质基础，同时也为多巴胺受体D2可以作为潜在镇痛药物靶点提供有力验证。

Pain seriously affects our health, while the current pain management is limited. Most of the pain medications induce undesirable tolerance and other side effects in many patients. Therefore, it is urgent to search for efficacious pain relievers with less side effects. Based on our previous work, the present project will integrate the advanced analytical chemistry techniques, cell-based screening and in vivo study to discover the active components from Corydalis yanhusuo W. T. Wang, which are able to modulate dopamine D2 receptors. The analgesic properties of the active components will be examined. This study will help to understand the mechanism behind TCMs by providing theoretical evidence and molecular basis. In addition, the results of this study will support the idea that dopamine D2 receptor may be a potential target for novel analgesics.