多囊卵巢综合征 (Polycystic ovary syndrome, PCOS) 的研究历经七十余年，对PCOS的认识已从单纯的育龄期妇女生殖功能障碍，演变为一种复杂、多系统的内分泌代谢疾病，不仅影响女性生殖内分泌功能，而且是发生糖尿病、子宫内膜癌、心血管疾病及脂代谢异常等远期并发症的罪魁。PCOS的发生是遗传和环境因素的共同影响，临床特征多样，不同民族、年龄阶段，遗传表型不尽相同，与基因甲基化相关，胰岛素抵抗是该病重要的病理生理学基础，VNTR、INSR、TCF7L2及Calpain-10基因的多态性与该病的发生、发展密切相关。本课题采用前瞻性及回顾性研究方法，对新疆PCOS维、汉及一级亲属进行调查，总结新疆维、汉PCOS妇女及一级亲属发病的关系，为阐明VNTR、INSR、TCF7L2及Calpain-10基因与新疆汉族、维吾尔族多囊卵巢综合症患者发病的关系，为该病的防治提供线索。

Polycystic ovary syndrome (Polycystic ovary syndrome, PCOS) have been studied. about seventy years, research on the understanding of the PCOS has shifted from the childbearing age women of reproductive dysfunction, evolved into a complex, multiple system of endocrine metabolic disease, not only affect the female reproductive endocrine function, and endometrial cancer and diabetes, cardiovascular disease and the long-term complications, such as lipid metabolism disorders. The occurrence of PCOS is a common genetic and environmental factors, clinical features and varied, the different regions, different nationalities, different ages, different performance, insulin resistance is important in the pathophysiology of the disease, VNTR, INSR, TCF7L2 and Calpain - 10 gene polymorphism and no correlation between the occurrence and development of the disease. This topic using prospective and retrospective study method of PCOS, han in xinjiang and the onset of first-degree relatives investigation, summarize d, han in xinjiang the pathogenesis of PCOS women and first-degree relatives relationship to clarify VNTR, INSR, TCF7L2 and Calpain - 10 genes and han Chinese and uighurs in xinjiang in patients with polycystic ovary syndrome, the relationship between disease to provide basis for prevention and control of the disease.