随着耐药微生物菌株的不断涌现，抗生素在感染类疾病治疗方面已无法取得明显优势，因此探索新的抗菌药物和技术手段迫在眉睫。相较于传统抗生素治疗，光诱导抗菌疗法（包括光动力治疗和光热治疗）作为一种非侵入治疗模式，具有创伤性小、毒性低、选择性好、可重复治疗以及不易产生耐药性等优点，在抗菌领域表现出优异的应用前景。虽然现有碳点光疗制剂能够对致病菌实现有效的光诱导灭活，但仍面临着前驱体合成路线复杂、成本高昂和选择性识别弱等问题，在临床应用中受到极大限制。因此，本项目拟通过从自然界广泛存在的天然生物质中筛选碳源，制备廉价、水溶、低毒和高效的碳点光疗制剂，深入研究和探索其对耐药菌的光诱导灭活性能以及在伤口敷料中的应用拓展，希望进一步挖掘此类碳纳米材料在生物医学研究领域中的潜能，为设计新型高效碳基光疗制剂提供必要的理论指导。

With the continuous emergence of drug-resistant microbial strains, antibiotic therapy has been unable to achieve excellent therapeutic effects on infectious diseases. Therefore, it is of paramount importance to develop highly effective bactericides and antibacterial techniques without multi-drug resistance. As one non-invasive treatment modes, photo-induced antibacterial therapies including photodynamic therapy and photothermal therapy show excellent prospects in the treatment of infectious diseases with prominent characteristics of minimal invasion, low toxicity, good selectivity, and repeatable treatment. More importantly, compared with conventional antibiotic therapy, pathogenic bacterium are less likely to produce drug resistance to photo-induced antibacterial therapies. Although carbon dots (CDs)-based phototherapy agents can effectively inactivate bacteria under light irradiation, their antibacterial applications have been greatly limited due to the complex synthetic route of precursors, high cost and weak selectivity and recognition. Therefore, in this project, with natural biomass as carbon source, a series of carbon dots (CDs) will be prepared for photo-induced bactericidal treatment. Furthermore, the in vitro and in vivo antibacterial activities of CD-based phototherapy agents will be in detail performed, as well as their antibacterial applications in wound dressings. The achievement obtained herein will not only further exploit the potentials of such carbon nanomaterials in the field of biomedical research, but also provide theoretical guidance for the design of novel high-efficient carbon-based antibacterial phototherapy agents.