炔烃途经亚乙烯基金属卡宾的催化转化

炔烃通过1,2-氢迁移得到的金属亚乙烯基卡宾是有机合成中一类非要重要的高活性中间体。这类中间体可以发生反马氏加成反应，碳环化反应以及周环反应等等。开发新型的基于金属亚乙烯基卡宾的转化化学一直以来都是过渡金属催化中的一个重要领域。在本项目中，我们计划通过不同催化体系的筛选分别实现基于金属亚乙烯基卡宾的苯环化反应和氧化苯环化反应。同时，我们还希望通过手性配体的调控实现炔烃反马氏加成的对映选择性。本项目还计划尝试开发新的金属催化剂尤其是铁基的催化剂来实现途经亚乙烯基金属卡宾的炔烃（以及具有挑战性的非末端炔烃）的催化转化。

Metal vinylidenes from alkynes via 1,2-H migration are important reactive intermediates in organic synthesis. It could undertake anti-Markovnikov hydrofunctionalization, carbocyclization as well as pericyclic reactions. Development of new catalytic transformations of alkynes based on metal vinylidenes is a significant research area in transition-metal catalysis. In this project we aim to achieve benzannulation or oxidative benzannulation reactions through metal vinylidenes by employing different catalysts system. We also plan to achieve the asymmetric anti-Markovnikov hydrofunctionalization of alkynes by screen different chiral ligands for Metal vinylidenes. Futher purpose for this project is to identify new catalysts especially Iron-based catalysts suitable for catalytic transformations of alkynes (including the challenged internal alkynes) via Metal Vinylidenes.