基于同步EEG-fMRI研究原发性早泄躯体感觉皮层与丘脑-额叶神经环路的动态失连接机制
结题报告
批准号:
82001793
项目类别:
青年科学基金项目
资助金额:
24.0 万元
负责人:
陆加明
依托单位:
学科分类:
磁共振成像
结题年份:
2023
批准年份:
2020
项目状态:
已结题
项目参与者:
陆加明
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中文摘要
原发性早泄(PE)是男性最常见的性功能障碍疾病,但PE的中枢发病机制尚不明确。课题组前期建立的躯体感觉诱发电位分类体系指导PE治疗获得显著效果,我们前期功能磁共振(fMRI)研究还发现PE患者丘脑-额叶环路的功能连接明显下降。然而该环路与躯体感觉皮层的连接是如何影响PE的发生还需深入研究。本项目在前期的脑功能研究基础上,继续纳入PE患者,进行临床行为学评估、阴茎体感诱发电位刺激,联合脑电(EEG)和fMRI,同步记录阴茎电刺激下中枢的电生理及脑功能活动。结合希尔伯特全息谱(HHSA)和溯源分析瞬时非稳态神经电信号,构建EEG-fMRI联合神经网络。以期寻找躯体感觉脑区与丘脑-额叶环路之间的相互关系,探寻躯体感觉在原发性早泄中枢神经环路中的作用,阐明原发性早泄神经电生理调控性行为的神经环路机制。本研究有助于深入理解原发性早泄中枢神经机制,为开辟新的早泄评估和疗效评价方法提供科学依据。
英文摘要
Primary premature ejaculation is the most common sexual dysfunction in male while the central nervous pathogenesis of primary premature ejaculation still remains unclear. Established by our research group, the classification system of somatosensory evoked potentials has been used to guide the treatment of premature ejaculation and provided a greater benefit. Our earlier functional magnetic resonance imaging (fMRI) studies also found that the functional connection between thalamus and frontal revealed significant decreased in PE patients. However, the connection between the somatosensory cortex and the thalamus-frontal neural circuit in PE need to be thoroughly probed. Based on previous studies of premature ejaculation, this study will continue to recruit PE patients for clinical behavioral assessment, penile somatosensory evoked potential stimulation. Brain electrophysiology and function activities will be recorded at the same time using electroencephalography (EEG) and fMRI under a high spatiotemporal resolution. By Holo-Hilbert Spectral Analysis and source modeling, we will try to decode the instant and dynamic neuro-electrophysiology signal features and build a neural network with EEG-fMRI. The purpose of this study is to find the relationship between brain somatosensory cortex and the thalamus-frontal circuit. Through this study, we will explore the role of somatosensory in the central neural circuit of primary premature ejaculation, and to clarify the mechanism of neural circuit electrophysiological regulation in primary premature ejaculation. This study is helpful for a deep understanding of the central nervous system of primary premature ejaculation, and provides a scientific basis for the development of new assessments and curative effects of premature ejaculation.
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DOI:10.3389/fnagi.2021.646017
发表时间:2021
期刊:Frontiers in aging neuroscience
影响因子:4.8
作者:Chen Q;Lu J;Zhang X;Sun Y;Chen W;Li X;Zhang W;Qing Z;Zhang B
通讯作者:Zhang B
DOI:10.3389/fnins.2021.721236
发表时间:2021
期刊:Frontiers in neuroscience
影响因子:4.3
作者:Lu J;Chen Q;Li D;Zhang W;Xing S;Wang J;Zhang X;Liu J;Qing Z;Dai Y;Zhang B
通讯作者:Zhang B
国内基金
海外基金