研究发现的Th17/Treg细胞及其失衡理论改变了传统的Th1/Th2失衡的理论，而最新发现的Th9细胞在众多免疫系统疾病中发挥了重要的作用，这些新型T辅助细胞是近年来银屑病发病机制研究的难点和热点。Th17可促进炎症因子的释放加重银屑病的病情，而Treg为具有免疫抑制作用的细胞群，两者作用相互拮抗。Th9细胞对此平衡有重要的调控作用。在前期研究凉血解毒立法消银解毒颗粒可调控 Th1、Th2 细胞亚群及其细胞因子的基础上。本课题针对Th17、Treg、Th9细胞及其相关因子，采用流式细胞术﹑Western blot﹑ Real-time PCR﹑双抗夹心ABC-ELISA等方法，以随机对照原则，对寻常型银屑病血热证患者治疗前后外周血进行检测；并在体外培养诱导分化人T淋巴细胞，观察药物对T细胞分化，及JAK/STAT信号传导通路激活的影响，为中药治疗银屑病提供新的理论基础及实验依据

Psoriasis is a T cells mediated autoimmune disease. The resent study found that new T cells Th17、Treg and their balance disorder theory changed the traditional theory that balance disorder of Th1/Th2, which is the most hot and difficult issuse on psoriasis's research.Th17 cells can promote inflammatory cytokines releaseing and aggravate the conditions of psoriasis, nevertheless Treg cells are the cells with immunosuppressive effective, which secrete mutiple anti-inflammtory cytokines,the functions between Th17 cells and Treg cells are oppsite,the balance of Th17/Treg disorder is one of the pathogenesis of autoimmune disease.Our previous research has suggested Xiaoyin Jiedu granules can treat psoriasis by control balance disorder of Th1/Th2 and related-cytokines.On this basis, this subject focus on Th17 cells、Treg cells and their related-cytokines, use methods of flow cytometry、immunochemistry techenique、Western blot、Real-time PCR and ABC-ELISA, with randmized controlled principle, detection of peripheral blood、lesion before and after the treatment, external pharmacological Serum experiment at the same time, explore the therapeutical effect and immune mechanism of the traditional Chineses treatment by cooling blood and removing toxins, then provide foundations and experimental proofs for using traditional Chinese medicine to treat psoriasis.