基于石墨烯的表面增强红外吸收型（SEIRA）传感器可用于检测生物分子的振动指纹谱，具有灵敏度高、可动态调谐等优点，在病毒检测、药物筛选等医疗健康领域中具有重要的研究意义。然而，目前的石墨烯SEIRA生物传感器普遍只具有单一的谐振模式且器件稳定性较差，这限制了其在复合生物分子识别中的应用。本项目拟采用基于石墨烯的多谐振型超表面结构，实现SEIRA传感器对复合生物分子指纹谱的同时检测和识别，研究超表面结构对指纹谱信号的增强机制。研究内容包括：建立多谐振型石墨烯SEIRA传感器理论模型，揭示光与传感器、生物分子之间的相互作用规律；制备稳定的多谐振型石墨烯SEIRA传感器，进行器件表征测试与物理性能分析；利用所制备的传感器对复合生物样品进行实测研究，分析传感器的生物相容性和稳定性。研究成果将为研制多谐振型石墨烯SEIRA传感器提供理论基础和科学依据，为制备稳定的石墨烯生物传感器提供必要的技术支撑。

Graphene-based biosensors utilizing surface enhanced infrared absorption (SEIRA) open up exciting possibilities for detection of biomolecules through their vibrational fingerprints, which is important in virus detection and drug screening. Due to the extreme spatial light confinement in graphene, graphene biosensors show superior sensitivities. Moreover, their resonances can also be tuned dynamically. Nowadays, SEIRA biosensors based on graphene usually show single resonance and instability, which limit their further applications in the identification of composite biomolecules. In this project, we intend to employ a multi-resonant metasurface based on graphene to detect and distinguish the composite vibrational fingerprints in biomolecules simultaneously, aiming to study the enhancement mechanism of the metasurface for the vibrational fingerprints. We will build physical models of multi-resonant graphene SEIRA biosensors and study the interactions among the incidence, biosensors and biomolecules. Next, we will fabricate durable multi-resonant graphene SEIRA biosensors and analyze the physical performance. Lastly, we will apply the fabricated biosensors into the detection of composite vibrational fingerprints in the heterogeneous samples and identify multiple biomolecules while analyzing the biocompatibility and stability simultaneously. The research achievement will provide theoretical basics and experimental guides for stable and durable multi-resonant graphene-based SEIRA biosensors.