基于Hantzsch反应的高通量高分子合成体系

高通量合成含有大量样本的高分子库有助于深入了解高分子结构与性能之间的关系，也为发现新型功能高分子提供了机遇。利用多组分反应高通量合成高分子是高分子科学的新领域，然而，这一领域尚存在合成随意性较大、表征手段匮乏、合成效率有待进一步提高等问题。本项目拟发展基于Hantzsch反应的高通量高分子合成体系，在明确合成目的的前提下，提高合成效率并探索新的高通量表征方法。我们拟利用Hantzsch反应的特点（产物具有潜在生物活性、底物广泛易得、反应高效快速且耐受性好），将其与自由基聚合相结合，一锅法高通量合成抗菌、抗氧化的功能高分子；同时，我们也拟将Hantzsch反应与不同多组分反应相结合，高通量合成含有不同多组分结构的缩聚物库。通过本项目，我们将建立特色鲜明的、基于Hantzsch反应的高通量高分子合成体系，为深入研究含二氢吡啶聚合物独特的物理化学性质和功能、探索其潜在应用打下坚实的基础。

High-throughput (HTP) synthesis of polymer libraries containing plenty of samples is helpful to understand the relationship between polymer structures and properties, and offers new opportunities to discover new functional polymers. HTP synthesis polymer via multicomponent reactions (MCRs) is a new area in polymer science. However, there are still some problems in this area including great randomness of synthesis and lack of HTP characterization methods, and the synthesis efficiency needs to be further improved. In this project, we will develop a HTP polymer synthesis system based on the Hantzsch reaction to clarify the purpose of HTP polymer synthesis, improve the HTP synthesis efficiency, and explore new HTP characterization methods. We intend to combine the Hantzsch reaction with free radical polymerization to develop a one-pot HTP synthesis to prepare antibacterial or antioxidant polymers by taking advantage of the features of the Hantzsch reaction (potential bioactive products, easily available substrates, highly efficient and robust reaction, etc.). We will also combine the Hantzsch reaction with other MCRs to synthesize libraries of polycondensates containing different multicomponent structures. By this project, we will establish a distinctive HTP polymer synthesis system based on the Hantzsch reaction, which will lay a solid foundation for in-depth study of the unique physical and chemical properties/functions of dihydropyridine containing polymers to explore their potential applications.