水环境中污染物可与纳米颗粒结合而改变污染物的环境化学行为、生物可利用性乃至毒性效应。本项目以典型溴代阻燃剂十溴联苯醚（BDE209）及十溴二苯乙烷（DBDPE）为对象，建立沉积物暴露生物毒性效应评价，水体中纳米二氧化钛（n-TiO2）与BDE-209、DBDPE吸附、结合的分析方法，阐释n-TiO2与BDE-209、DBDPE相互作用的物理化学特征及溶解性有机碳（DOC）的影响。以斑马鱼为对象，通过长期低剂量单一和存在n-TiO2、DOC 时的暴露，研究BDE209、DBDPE的生物可利用性、毒代动力学、组织器官分布特征、代谢以及对斑马鱼的甲状腺内分泌干扰效应，探究n-TiO2和DOC影响BDE209、DBDPE毒性效应的机制，揭示自然水体中低剂量BDE209、DBDPE与n-TiO2相互作用引起的潜在生态环境风险。本研究可为全面评估实际水环境中溴代阻燃剂的生态毒理学效应提供科学数据支持。

Organic toxicants can interact with nanoparticles (NPs) in the aquatic environment, which may modify toxicant’s environmental behavior, bioavailability and consequently the toxicity to aquatic organisms. In this project, the typical organic toxicants, i.e., BDE209 and its alternative DBDPE will be selected, and we will investigate the potential toxicity upon sediments exposure, the physiochemical interactions (e.g., adsorption, binding), between BDE209, and its alternative DBDPE with titanium dioxide NPs (n-TiO2), and natural dissolved organic carbons (DOC).The zebrafish will be selected as model fish, and we will examine the impact on bioconcentration/bioavailability, toxicokinetics, metabolism/biotransformation, tissues distribution of organic toxicants after long-term exposure to BDE209, DBDPE with or without n-TiO2/DOC. As potential toxicity, we will focus on thyroid endocrine disruptive effects on both parental (F0) and their next generation (F1). The present project will understand the influences of n-TiO2/DOC on the bioavailability and toxicity of environmental concentrations of BDE209/DBDPE in the aquatic environment and thus contribute to assessment of potential ecotoxicological impact on aquatic organisms.