空气细颗粒物及环境条件对SARS-CoV-2等典型冠状病毒传播影响研究

批准号:
92043201
项目类别:
重大研究计划
资助金额:
300.0 万元
负责人:
徐东群
依托单位:
学科分类:
环境毒理与健康
结题年份:
2023
批准年份:
2020
项目状态:
已结题
项目参与者:
徐东群
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中文摘要
本项目对应指南重点资助研究方向 “3.空气细颗粒物对SARS-CoV-2等典型冠状病毒环境传输的影响”。选择特定的有限空间,了解其中颗粒物的分布特征;制备与特定有限空间粒径分布相同的聚苯乙烯微球颗粒物,保证雾化后分散的稳定性,在模拟舱中测量、计算不同粒径粒子的扩散系数、沉降系数和穿透系数,建立不同气流组织布局和通风模式下,有限空间内颗粒物扩散数值模拟模型;在符合生物安全要求的条件下,利用呼吸型小鼠肝炎病毒(MHV-1)模拟不同呼吸频率和打喷嚏等的呼气量,研究颗粒物及不同环境条件对病毒载量、粒径分布和存活时间等的影响,建立多元回归模型;利用人普通冠状病毒OC43(HCoV-OC43)及新冠病毒进行验证,优化模型;整合数值模拟和经验模型,建立评价模型,揭示细颗粒物及气流组织布局、通风模式和温湿度等环境条件对新冠等冠状病毒的潜在影响,为阻断新冠病毒等冠状病毒的空气传播及感染提供科学依据。
英文摘要
This project corresponds to the guide's key funding research direction "3. The impact of airborne fine particles on the environmental transmission of SARS-CoV-2 and other typical corona-viruses". We will choose specific indoor environment or public transport (limited space) to understand the distribution characteristics of particulate matters. The polystyrene microspheres with the same particle size distribution as the specific limited space will be prepared to ensure the stability of dispersion after atomization. The diffusion coefficient, sedimentation coefficient and penetration coefficient of particles of different size in the simulation test chamber will be measured and calculated to establish numerical simulation model of particulate matters’ diffusion in limited space under different layout of airflow and ventilation mode. In accordance with the requirements of bio-safety, the respiratory type mouse hepatitis virus (MHV-1) will be used to simulate the exhalation of different respiratory frequencies and sneezing, and to study the effects of particulate matters and different environmental conditions on the viral load, particle size distribution, and survival time, etc., and to establish a multiple regression model. The model will be optimized by using human common corona-virus OC43(HCoV-OC43) and SARS-CoV-2. By integrating numerical simulation and empirical model, an evaluation model will be established to reveal the potential influence of fine particles, air distribution, ventilation pattern, temperature and humidity on SARS-CoV-2 and other typical corona-viruses. It will provide scientific basis for blocking SARS-CoV-2 and other typical corona-viruses airborne transmission and infection.
期刊论文列表
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科研奖励列表
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专利列表
DOI:10.1016/j.scitotenv.2021.146040
发表时间:2021-07-15
期刊:The Science of the total environment
影响因子:--
作者:Li X;Wang Q;Ding P;Cha Y;Mao Y;Ding C;Gu W;Wang Y;Ying B;Zhao X;Pan L;Li Y;Chang J;Meng C;Zhou J;Tang Z;Sun R;Deng F;Wang C;Li L;Wang J;MacIntyre CR;Wu Z;Feng Z;Tang S;Xu D
通讯作者:Xu D
DOI:10.46234/ccdcw2022.030
发表时间:2022
期刊:China CDC Weekly
影响因子:4.7
作者:Li Xia;Zhang Zhuona;Lyu Keyang;Xu Dongqun
通讯作者:Xu Dongqun
DOI:10.46234/ccdcw2022.123
发表时间:2022-07-01
期刊:CHINA CDC WEEKLY
影响因子:4.7
作者:Mao, Yixin;Luo, Yueyun;Zhang, Wenda;Ding, Pei;Li, Xia;Deng, Fuchang;Xu, Kaiqiang;Hou, Min;Ding, Cheng;Wang, Youbin;Dong, Zhaomin;MacIntyre, Raina;Yao, Xiaoyuan;Tang, Song;Xu, Dongqun
通讯作者:Xu, Dongqun
DOI:10.46234/ccdcw2021.212
发表时间:2021-10-08
期刊:China CDC weekly
影响因子:4.7
作者:Xu D;Zhang Z;Wang Q;Li X
通讯作者:Li X
DOI:10.1016/j.eti.2021.102165
发表时间:2022-03
期刊:Environmental technology & innovation
影响因子:7.1
作者:Li X;Ding P;Deng F;Mao Y;Zhou L;Ding C;Wang Y;Luo Y;Zhou Y;MacIntyre CR;Tang S;Xu D;Shi X
通讯作者:Shi X
国内基金
海外基金
