脑胶质瘤这种脑神经中枢恶性肿瘤以发病快、发现难、死亡率高逐渐威胁着人们的身体健康，实现对其有效治疗一直以来都是亟待解决的核心科学问题之一。本项目提出利用一种复合型磁性纳米靶向药物，通过磁力开关控制其药物释放，实现化疗和磁力机械杀伤共同作用，从而增强脑胶质瘤细胞死亡的方法。其研究思路为，利用聚乳酸-羟基乙酸共聚物共同包载磁响应能力强的磁性纳米粒子和抗癌药物阿霉素，并在外表面修饰脑胶质瘤靶向多肽分子Angiopep-2形成复合型磁性纳米靶向药物，提高药物递送准确性，通过外旋转磁场控制阿霉素释放，引导磁性纳米粒子机械运动产生旋转撕扯力，从而增强脑胶质瘤细胞的死亡，实现安全、可控、准确和高效地杀灭脑胶质瘤细胞的目标。该项目的有效实施，将为脑胶质瘤的治疗提供一种新途径，并能促进脑胶质瘤的基础研究，且有望为日后可控型抗肿瘤药物的研发和肿瘤的临床治疗打下坚实的基础。

The malignant brain tumor is gradually threatening people’s health. Among them, glioma is known as one of the horrible diseases due to its properties which are quick pathogenesis, non-easy detectable and very high death rate. How to realize an effective therapy of brain cancer is one of the key problems to be solved in the field of biomedical science. This project proposes a method towards magnetic composite nanoparticles with target molecules to control adsorption and release of anti-cancer drugs by magnetic switch. The magnetic induced mechanical force enhances chemotherapy effect to lead the death of glioma cells. The key point will be how to lead the magnetic nanocomposite to control adsorbing and releasing the anti-cancer drugs and induce the mechanical shear force for enhancing the death of glioma cells efficiently and safely. The specific details are: Firstly, magnetic nanoparticles and anti-cancer drugs are loaded by poly (lactic-co-glycolic acid) (PLGA). Secondly, the targeted polypeptide molecules Angiopep-2 are coupled with the co-loaded PLGA NPs. Thirdly, the external magnetic field control absorption and releasing anti-cancer drugs. Fourthly, the mechanical shear force and chemotherapy are cooperated for enhancing the death of glioma cells. This project will provide a safe, controllable and effective therapy for curing brain cancer, and will promote the fundamental research of glioma. In addition, this project will do lay a solid foundation for developing a novel, efficient and low side-effect drug or therapy of glioblastoma.