中医认为醋炙乳香增强散瘀止痛、疏肝行气功效，但醋炙的药效物质基础及机理不清楚。国际上使用乳香提取物存在生物利用度低的难题。本研究在前期工作基础上，将传统制药技术与现代科学技术相结合，探究醋炙后乳香多糖发生物理和化学改性情况、构-效关系及协调萜类作用，为活性多糖的发现和改造提供理论指导；研究醋乳香多糖对萜类成分乳化性能的改善、肠道代谢的保护、摄入型转运多肽（OATPs）的调节，从多角度、多层次阐明醋炙乳香增强萜类成分生物利用度的机制。通过本研究不仅将现代国际上存在的乳香萜类提取物生物利用度低的难题通过传统制药技术加以解决，而且通过现代先进技术阐明传统中药制药的科学内涵，是对传统理论的继承和创新。形成的“多糖改性-乳化性-CES2-OATPs”研究模式，将为乳香炮制、质量指控及开发乳香类新药提供强有力的科学依据，推动中药炮制学、中药化学、中药药剂学等多学科交叉与融合，为同类中药研究提供借鉴。

Traditional Chinese medicine believes that vinegar-fried frankincense can enhance the effect of dispersing blood stasis and relieving pain, soothing liver and promoting qi, but the material basis and mechanism of vinegar-fried frankincense are not clear. There is a bottleneck of low bioavailability in the use of frankincense extracts in the world. On the basis of previous work, we combines traditional pharmaceutical technology with modern science and technology, explores the physical and chemical modification, structure-activity relationship and coordination of frankincense polysaccharides for triterpenoids after vinegar-fried, which can provide theoretical guidance for the discovery and modification of active polysaccharides; studies the improvement of emulsifying properties of terpenoids through polysaccharides of frankincense vinegar-fried, the protection of intestinal metabolism, and intake-type the regulation of organic anion transporting polypeptides (OATPs) , clarifies the mechanism of enhancing the bioavailability of terpenoids in processed frankincense with vinegar from multiple perspectives and levels. In this study, we not only solve the problem of low bioavailability of frankincense terpenoids extracts in the modern world through traditional pharmaceutical technology, but also clarify the scientific connotation of traditional Chinese medicine pharmaceuticals through modern advanced technology, which is the inheritance and innovation of traditional theory. The "polysaccharide modification-emulsification-CES2-OATPs" mode formed will provide a strong scientific basis for frankincense processing, quality control and development of new drugs, and promote discipline Intersection and Integration such as traditional Chinese medicine processing, traditional Chinese medicine chemistry, and traditional Chinese medicine pharmacy and provide research ideas for similar Chinese medicine.