目前，在我国许多江河水中检出抗生素残留，对生态环境和人类健康造成严重威胁。本研究综合利用介孔硅材料和荧光传感器阵列的优势，以介孔硅材料为固体基质，萘二甲酰亚胺为荧光报告基团，通过改变识别基团和连接基团，制备24种功能化介孔硅/金属杂化材料。利用交叉响应性的原理，本研究力图发展基于功能化介孔硅/金属杂化材料的荧光传感器阵列新方法，达到对8种典型磺胺类抗生素（SAs）选择性、灵敏和快速同时检测的目的，并应用于邕江、柳江、漓江、西江和南流江水体中SAs种类的快速鉴定和定量分析。本项目有效地解决SAs检测体系所面临的水溶性较差和选择性较差的缺陷，相关研究未见报道，为阵列荧光传感器的发展提供了新的思路，并有望应用于其它分析对象和其它检测领域，应用前景广阔。

Currently, antibiotics residues have been detected from many rivers in China, which poses a serious threat to ecological environment and human health. In this research, 24 kinds of functional mesoporous silica/metal hybrid materials was fabricated, by utilizing the advantages of mesoporous silica materials and fluorescent sensor arrays comprehensively, mesoporous silica was used as the solid support, naphthalimide was selected as the fluorescent reporter group, the recognition group and the spacer group were adjusted. This research targeted at developing a new method of fluorescent sensor arrays through cross-reactive principle, based on functional mesoporous silica/metal hybrid materials, in order to achieve the purpose of selective, sensitive and rapid simultaneous detection of 8 typical sulfonamide antibiotics (SAs); the new method will be explored to the rapid identification and quantitative analysis of SAs species in the water solutions of Yongjiang River, Liujiang River, Lijiang River, Xijiang River and Nanliujiang River. This project solved the deficiencies of SAs detecting systems effectively, such as poor water solubility and low selectivity, the relevant research has not been reported, this research provides a new idea for the development of fluorescence sensor arrays, and is expected to be applied to other analytical objects and other detection areas which has broad application prospects.