疼痛是临床中最为常见的症状之一，严重影响人的生活质量和工作效率。如何有效地缓解疼痛，寻找替代性非药物疗法已经成为重要的科学、社会和经济议题。音乐作为被临床实践证实可有效缓解疼痛的手段，因其无损伤、易获取、易操作等优势得到了多个领域学者的关注。但目前音乐镇痛效应的心理和生理机制仍不明确，因此本研究旨在（1）研究不同音乐属性对不同类型疼痛镇痛效果的影响；（2）研究个体差异对不同类型疼痛镇痛效果的影响；（3）探究音乐属性和个体差异在不同类型疼痛中的镇痛效果的交互作用，建立音乐镇痛的最优模型；（4）结合不同音乐条件下，疼痛的EEG响应特征和其他相关生理特征，探究音乐镇痛的心理和生理机制；（5）在健康志愿者和临床神经病理性疼痛人群中检验音乐镇痛最优模型的有效性。本研究结果将为应对伤害性疼痛和治疗慢性疼痛等临床工作提供重要的理论依据和技术支持，促进实验结果向临床应用转化，帮助减轻甚至去除病人的痛苦。

As one of common symptoms in clinical practice, pain affects one’s life quality in many ways. To reduce pain, it is necessary to come up with alternatives to pharmaceutical treatments. The capacity of music to soothe pain has been widely reported and acknowledged across different research areas. Yet, the underlying mechanisms of music-induced analgesia are still unclear. To provide further insights into this analgesic effect, the proposed project aims to (1) investigate which music features that contribute to pain reduction for different types of pain; (2) explore the influences of individual differences on the analgesic effect for different types of pain; (3) examine the interactions between music features and individual differences on pain reduction, thereby establishing the optimal model; (4) reveal the underlying mechanisms of music-induced analgesia by using EEG and other related physiological data; and (5) test the model among healthy individuals and patients suffering with neuropathic pain. By providing theoretical foundation and technical support, this project will translate the laboratory findings to clinical practice, such as coping with nociceptive pain and curing neuropathic pain, which would help relief patients from pain.