ERP在视野客观评价中的应用及视野信息刺激的大脑投射加工机制研究

在临床和法医学鉴定实践中，常存在病人不能陈述或被鉴定人有目的地伪装或夸大视野缺损程度的问题，目前常用的主观检查方法不能对被试者的视野进行客观评价，更无法评价中枢性损害引起的视野缺损，视野信息的大脑投射及加工机制也是脑科学中亟待研究的课题。本申请项目在我们前期工作基础上，拟采用事件相关电位（ERP）等脑科学研究技术开展以下研究：1.建立与多焦VEP相兼容的视野ERPs刺激模块，以及左/右视野、上/下视野、中心/周边视野刺激模块；2.对各种刺激模块所引发的ERPs成分进行时空分析和脑网络构建，建立ERPs特征成分与视野刺激的相关性；3.联合应用ERPs、核磁共振（MRI及fMRI）和功能性近红外光谱（fNIRS）技术，研究不同视野信息投射的脑定位和网络加工机制。本研究将为中枢及外周损伤或疾病所致视野缺损提供客观检测及诊断手段，并为视野信息的大脑投射及加工机制提出新理论。

In clinical and forensic practice, there are lots of patients who cannot tell their visual filed clearly, and even exaggerate their visual defect problems. However, the current commonly used perimetry cannot objectively evaluate the subjects of their vision field, not to say to detect the central nervous system damage caused visual field deflects. In addition, the central nervous mechanism of the visual field projection is still not clear. Based on our previous works on visual acuity, this project intends to adopt event-related potentials (ERPs) etc. to carry out the following studies: 1. To establish a ERPs-stimulus paradigm that is compatible with multifocal VEPs, and to establish left and right/ upper and lower/central and peripheral visual field stimulation module; 2. To conduct ERPs triggered by the paradigm of visual stimuli frequency and brain network analysis and found the characteristic components and visual field; 3.combined application of ERPs, MRI, fMRI and functional near-infrared spectroscopy (fNIRS) to explore the mechanism of brain processing on different visual field information stimuli. The research of this subject will provide technical means for the objective examination of visual field defects in forensic and clinical practice, and provide new theory for brain processing mechanism on visual field projection.