客观视力检测一直是法医临床鉴定领域的难题，认知事件相关电位(ERPs)技术为解决这一难题提供了手段。我们近几年研究发现：不同视角的视觉信息刺激可引起大脑ERPs外源性和内源性成分的特征性变化，且不受主观控制，说明通过多点全程ERPs分析技术可以确定个体客观视力水平。故本项目拟开展以下工作：①建立与标准视力表相匹配的全视角视觉信息ERP刺激模块，研究视角对脑信息加工的影响，并确定与每个视力相对应的阈值视角ERP刺激模块；②用阈值视角刺激模块筛选出能诱导最佳ERPs的最佳刺激距离；③建立阈值视角刺激流模块，在最佳刺激距离引出与所有视力相对应的全程ERPs，多导联综合分析确立最佳阈值视角刺激流范式；④应用最佳刺激流范式对不同年龄的志愿者及不同病因的视力障碍病人进行检测及溯源分析，研究年龄及病因对ERPs的影响，完善视力相关ERPs分析标准。项目的目标是为客观视力检测提供理论依据和技术手段。

Objectively assessment of visual acuity is unsolved problems in clinical forensic practice. Cognitive event-related potentials (ERPs) study found that visual angle, and visual acuity are affecting visual cognitive processing of the brain,but no systematic study of the whole process was performed up to date.Our previous study found that: different visual angle and visual acuity led to changes in ERPs components P1 and P3, and P3 is matched with the reflection of brain function to the stimulation. Based on our previous work, we try to use ERP for the following studies in this project: ①Establish ERPs stimules model to assess the effect of visual angle on ERPs; ②Establish ERPs stimules model to certify the visual stimulating distance at same visual angle; ③Establish ERPs stimulus flow to obtain the best components of ERPs at the same visual acuity; ④Certificate the best ERPs stimulus flow mode by analysing the ERPs components and origination by blind testing. The aim of this project is to establish brain visual information processing model for visual acuity assessment to provide objective and scientific testing methods.