肿瘤间质流场力学特性异常与肿瘤淋巴转移有关，但其影响肿瘤淋巴转移的确切机制尚不明了。本课题拟在前期研究工作的基础上，试图运用分子量可控的对比剂HA-Gd-DTPA通过磁共振分子影像及功能成像的方法来建立评估肿瘤间质流场力学特性的影像学模型，同时对比肿瘤转移与非转移组之间肿瘤间质流场力学特性变化，并将肿瘤淋巴转移中重要的生物学因素包括肿瘤淋巴生成，肿瘤粘附因子表达与肿瘤间质流场力学特性改变相结合，分析肿瘤间质流场力学特性改变-粘附因子表达-肿瘤淋巴转移之间的先后关系和量级关系，从而将肿瘤淋巴转移过程中两个截然分开的机械因素及生物因素变成一个连续、统一、动态的研究过程。本研究将有助于揭示肿瘤间质流场力学特性影响肿瘤淋巴转移相关因素的作用及其机制，并为肿瘤淋巴转移机制研究的开展和临床无创评估肿瘤间质流场力学特性提供新的技术手段。

The abnormity in tumor interstitial fluid-flow mechanic characteristic is relevance to lymphatic metastasis. However, the exact role of the abnormity in tumor interstitial fluid-flow mechanic in tumor lymphatic metastasis is unknown. The purpose of this study is to establish the imaging model of magnetic resonance functional imaging to evaluate the tumor interstitial fluid-flow mechanic characteristic using the contrast agent HA-Gd-DTPA with controllable molecular weight synthetized in our previous research. With the comparison of the difference in tumor interstitial fluid-flow mechanic characteristic between objectives with and without lymphatic metastasis, as well as the connection of mechanical factors and biological factors in lymphatic metastasis, we aim to combine the mechanical and biological factors, which is separated in general cases, into a continuous, unified, dynamic research process to study the relation among the abnormity in tumor interstitial fluid-flow mechanic characteristic, expression of tumor adhesion factor. This study will help to reveal the mechanism of tumor interstitial fluid-flow mechanic characteristic to promote lymphatic metastasis. Meanwhile, it will provide a new modality for further research of tumor lymphatic metastasis and noninvasive evaluation of tumor interstitial fluid-flow mechanic characteristic.