当前，恶性肿瘤严重威胁着人类健康，对其进行及时诊断和治疗尤为重要。与传统光学成像相比，光声成像（PAI）具有非入侵性、深穿透性（穿透深度达毫米至厘米级）和高时空分辨率等优点。光热疗法（PTT）是一种具有非入侵性、特异性强、时空控制精确等优点的肿瘤治疗方法。将PAI和PTT结合的诊疗一体化技术展现出巨大临床应用潜力。光声和光热效应均与热能有关。因此，提高激发态分子非辐射衰减能量耗散是设计高效的PAI/PTT材料的关键。.近年来，聚集诱导发光（AIE）材料发展迅速，其研究重点主要集中于抑制聚集态分子运动，激活辐射衰减以增强荧光，但其非辐射衰减过程却鲜少被关注。.本项目拟利用AIE材料分子运动来提高非辐射衰减过程。通过合理的结构设计与优化，制备出一系列基于梯形稠环芳烃单元、高光热转换效率、近红外AIE小分子，进而研究分子结构与发光/光热性质的构效关系，并拓展AIE材料在PAI指导的PTT应用。

At present, malignant tumor is a serious threat to human health, its timely diagnosis and therapy is of great importance. Compared with traditional optical imaging, photoacoustic imaging (PAI) has the advantages of non-invasive, deep penetration(the penetration depth reaches millimeter to centimeter level) and high spatial-temporal resolution. Photothermal therapy (PTT) is a tumor therapy method with the advantages of non-invasive, specific, precise time-space controllability. The integration of PAI and PTT shows great potential in clinical application. Photoacoustic and photothermal effects are related to thermal energy. Therefore, the key to design efficient PAI/ PTT materials is to improve the non radiation energy dissipation of excited molecules..In recent years, the aggregation induced emission (AIE) materials have developed rapidly. The research mainly focuses on the inhibition of the movement of aggregation molecules and the activation of radiation decay to enhance fluorescence, but its non radiation decay process is rarely concerned..In this project, the molecular motion of AIE material is used to improve the non radiation attenuation process. Through reasonable structure design and optimization, a series of near infrared small molecules based on ladder-type multifused arene units with aggregation-induced emission characteristics and high photothermal conversion efficiency would be prepared, and then the relationship between molecular structure and luminescent/photothermal properties would be studied, and the application of AIE materials in PAI-guided PTT would be expanded.