肉鸡肠毒综合征是一种以腹泻、脱水、肠腔中含有未消化的饲料、采食量下降、生长缓慢，以及突然猝死为主要特征的疾病，近年来呈流行上升趋势，新产玉米是主要的诱因之一，但对其诱病的作用机制的研究目前仍处于探索阶段。代谢组学技术是系统生物学的研究方法之一，它可以从整体的、动态的角度来研究新产玉米对机体的作用机制。前期研究证明，增加新产玉米添加量显著降低肉鸡生长性能，并成功构建肉鸡肠毒综合征动物模型。本研究将运用代谢组学技术进行以下研究：建立新产玉米诱导肉鸡肠毒综合征的核磁共振谱；对新产玉米的生物代谢产物进行定性定量分析，筛选模型肉鸡血清、肝脏、肾脏和粪尿液中能够反映其致病的特征代谢物，并分析新产玉米对这些特征代谢物的影响；绘制新产玉米诱导肉鸡肠毒综合征的代谢网络；最终，利用代谢组学的理论、参照文献探讨新产玉米诱导该病的作用机理，为该病的机制研究提供新的思路和参考。

Broiler intestinal toxicity syndrome (BITS) is a disease characterized by diarrhea, dehydration, undigested feeds accumulated in the intestinal canal，lower feed intake, poor growth, and died suddenly. This syndrome is prevalencing in recent years, and new harvested maize is one of the major cause. However, its mechanism of action is still on the exploratory stage. As a systematic biology research method, metabonomics studies the mechanism of new harvested maize on organisms from a holistic, dynamic point of view. Preliminary studies have shown that broilers’ performance is significant lower as the increasing of new harvested maize dose, and BITS is successful built as well. This study will use NMR-based metabonomics to conduct the following studies: to establish NMR spectroscopy of BITS caused by new harvested maize, to conduct qualitative and quantitative analysis on biological metabolites of new harvested maize, to screen the characteristic metabolites in model broilers' serum, liver, kidney, faeces and urine that can reflect the noxious effect, and analyze the effect of new harvested maize on these characteristic metabolites, to explore the metabonomic approach of new harvested maize on the model broilers, and finally, based on the above results, to explore the inducing mechanism of new harvested maize on the model broilers according to the theory of metabonomics and literatures so as to providing a new idea for researcher on mechanisms of BITS.