慢性非可控性炎症是导致结肠炎相关性结肠癌发生的关键推动力，阻止急性炎症向慢性非可控性炎症转化可能是有效干预结肠癌发生的新策略。巨噬细胞表型转化在慢性非可控炎症的发生发展中具有重要的作用。前期研究发现五味子乙素Schisandrin B（Sch B）能够调控巨噬细胞表型转化，并显著抑制AOM/DSS诱导的结肠癌发生，但其作用机制未明。基于前期结果，申请者拟开展如下工作：1）结肠巨噬细胞表型转化与结肠慢性非可控炎症的关系；2）寻找并确证Sch B调控巨噬细胞表型转化的靶点，探索Sch B调控巨噬细胞表型转化的作用机制； 3）追踪结肠癌起始细胞形成的时间及数量，分析调控结肠癌起始细胞形成的信号通路、关键节点及其生物学特征。本项目的开展有助于开发新的预防性药物靶点，推动人们认识炎症向肿瘤转化的本质。

Chronic non-resolving inflammation is a key driving force for the development of colitis-associated colon cancer. Preventing the transition from acute inflammation to chronic non-controllable inflammation may be a new strategy to effectively interfere with the occurrence of colon cancer. Macrophage polarization plays an important role in the development of chronic non-resolving inflammation. Our previous study found that Schisandrin B (Sch B) can regulate macrophage phenotype polarization and significantly inhibit AOM/DSS-induced colon cancer, but the mechanism is unknown. Based on the previous results, our group plans to carry out the following work: 1) The relationship between macrophage polarization and colon chronic uncontrolled inflammation; 2) Finding and confirming the target of Sch B in regulation macrophage polarization and exploring the mechanism of Sch B regulation of macrophages polarization. 3) Tracking the time and number of colon cancer initiating cells, analyzing signal pathways, and biological characteristics that regulate the formation of colon cancer initiating cells. The development of this project will help develop new preventive drug targets and promote the understanding of the nature of inflammation and tumor transformation.