短链氯化石蜡（SCCPs）在动植物体内的蓄积和消除行为研究对评估其对环境和人体的预期风险具有重要意义，然而生物活体中SCCPs的高效和准确分析仍是目前环境分析化学领域极具挑战的科学难题。针对SCCPs易受干扰、难以分离、成分复杂、准确定量困难等难点问题，迫切需要发展对SCCPs具有选择性的生物活体样品前处理技术和高灵敏分离分析方法。有鉴于此，本项目拟通过探究多孔有机聚合物对SCCPs的富集行为和机理，研制对SCCPs具有选择性富集性能的新型固相微萃取探针，结合全二维气相色谱-高分辨质谱联用技术开发SCCPs的原位活体分析方法，最后应用于动植物活体中SCCPs的定性定量分析及其蓄积和消除行为的跟踪研究中。本项目研究将为环境分析新方法新技术的发展起到重要的促进作用，同时也可为SCCPs在生物体内的蓄积和消除行为研究提供有利的工具，具有重要的科学价值和实际意义。

It is of great significance to study the accumulation and elimination behavior of short-chain chlorinated paraffins (SCCPs) in animals and plants, for which will give us significant insights in evaluating the expected risk of SCCPs to the environment and human health. However, efficient and accurate analysis of trace SCCPs in living organisms is still a challenging scientific problem in the field of environmental analytical chemistry. In view of the challenges in SCCPs analysis such as susceptible to interference, difficult in separation, complex components, and difficult in accurate quantification, there is an urgent need to develop selective and in-vivo sample pretreatment techniques as well as highly sensitive analytical methods. To achieve this purpose, this project intends to investigate the enrichment behavior and mechanism of porous organic polymer toward SCCPs, and consequently develop a novel solid phase microextraction (SPME) fiber with high selectivity and enrichment ability for SCCPs. After that, the proposed SPME fiber is coupled with a comprehensive two-dimensional gas chromatography-high resolution mass spectrometry to develop an in-vivo analytical method for qualitative and quantitative investigation of the accumulation and elimination behaviors of SCCPs in animals and plants. This project will play an important role in promoting the development of new methods and new technologies for environmental analysis, and provide a powerful tool for investigation of the accumulation and elimination behaviors of SCCPs in organisms. The project has important scientific values and practical significances.