作为骨科植入材料，医用聚醚醚酮（PEEK）由于自身的生物惰性以及患者机体慢性炎症的病理状态所导致的植入后骨整合效果不佳是临床上亟需解决的难题。在PEEK表面进行生物功能化修饰对促进其骨整合效果具有积极意义。本研究拟利用新型等离子体浸没离子注入技术处理并活化PEEK表面，继而仅通过在溶液中孵育的方式，在其表面共价接枝包载有消退素D1的药物缓释脂质体，以及能够通过静电相互作用吸附阿仑膦酸钠的肝素。凭借体外实验及动物体内慢性炎症模型下的生物学效应评价，分别优化消退素D1和阿仑膦酸钠的负载量及释放趋势，以期在逆转植入材料局部组织的慢性炎症反应并发挥巨噬细胞免疫调控功能的基础上，提高骨髓间充质干细胞的成骨活性，并抑制破骨细胞的骨吸收活性。本项目的顺利实施有望探索出一种简便、高效的PEEK表面生物功能化修饰方法，从而为获得在慢性炎症病理状态下骨整合效果满足临床需要的新型骨科植入材料奠定理论和实验基础。

As an orthopedic implant material, PEEK suffers from poor osseointegration in vivo owing to its inherent bio-inertness under the pathological conditions of chronic inflammation, thus greatly limiting its clinical applications. Biological functionalization of PEEK surface is an effective way to enhance osseointegration. In this project, a novel plasma immersion ion implantation technique will be employed to activate the surface of PEEK. Then the liposomes which have encapsulated resolvin D1, and heparin which will adsorb alendronate via electrostatic interaction, can be covalently grafted onto PEEK surface only by incubation in respective solutions. The loading dosage and release profiles of resolvin D1 and alendronate will be optimized respectively with the feedback from biological evaluation using in vitro and in vivo chronic inflammatory models. The resultant surface is designed with the ability to reverse the chronic inflammatory response of peri-implant tissue and manipulate macrophage-mediated immunomodulation effects, thus enhancing the osteogenic differentiation of bone marrow mesenchymal stem cells and inhibiting the osteoclast-mediated bone resorption. The biological surface functionalization method proposed here is simple and effective, and will provide a theoretical and experimental basis for the development of a novel orthopedic implant, with its osseointegration performance meets the clinical needs even under the pathological conditions of chronic inflammation.