海马-前额叶同步振荡参与成瘾记忆再巩固的机制

药物成瘾严重影响人类健康和社会稳定，因机制尚不清楚，故缺乏有效的防复吸疗法。研究表明，成瘾记忆再巩固是吸毒患者复吸和成瘾模型动物复燃的重要机制，且有证据显示海马、前额叶协同参与成瘾记忆再巩固过程。最新的理论成果认为，同步振荡是记忆环路中不同脑区协同实现记忆处理的重要机制。我们的前期研究发现：（1）成瘾模型大鼠在成瘾记忆唤起后，发生海马-前额叶间振荡电活动同步化的动态改变；（2）海马-前额叶间的振荡同步化水平与成瘾记忆稳定性相关，说明海马-前额叶同步振荡参与成瘾记忆再巩固过程。本研究拟利用电生理同步记录结合多种信号分析方法，通过研究多巴胺在成瘾记忆唤起诱导海马-前额叶间同步振荡变化过程中的关键作用，以及同步振荡变化对海马-前额叶间信息传递强度和突触传递可塑性的影响，力图阐明海马-前额叶通过同步振荡协同参与成瘾记忆再巩固过程的机制，以期为探索成瘾后防复吸的新方法提供重要的理论依据。

Drug addiction greatly influence people’s health and society’s stability, while effective relapse preventing therapy was lacked because the mechanisms of addiction was poorly known. Researches suggested that addictive memory reconsolidation is the key mechanism of relapse by addicts and addictive animals, and some evidence showed that hippocampus and prefrontal cortex cooperate to participate in the addictive memory reconsolidation process. The most current theory thought that oscillatory synchronization is the important mechanism for memory process co-participated by different brain areas in the memory circuit. Our previous studies found:（1）There is dynamic changes of hippocampal-prefrontal oscillatory synchronization for addictive animals after addictive memory retrieval；（2）The level of hippocampal-prefrontal synchrony is associated with the stability of the addictive memory, suggested that hippocampal-prefrontal oscillatory synchronization was involved in the addictive memory reconsolidation process. The present study plan to apply the synchronized electrophysiological recordings combining various signal analysis methods, by studying the key role of dopamine in the hippocampal-prefrontal oscillatory synchronization induced by the addictive memory retrieval, and the influence of the synchrony on the information transmission strenghth and synaptic plasticity between the hippocampus and the prefrontal cortex, to clarify how the hippocampus and the prefrontal cortex cooperated to participate in the addictive memory reconsolidation through the oscillatory synchronization, and the study will supply the important theoretical basis for exploring the new relapse preventing method after addiction.