手性异特窗酸及其氮类似物（3-取代吡咯烷-2-酮）在天然产物中广泛存在，含有此两类结构的化合物具有重要的生理活性。然而合成这两类手性结构的催化方法学并不多见。发展手性催化反应来合成各种取代的手性异特窗酸及3-取代吡咯烷-2-酮非常重要。本项目从b-重氮-a-酮酸酯作为亲核试剂出发，拟以发展两类全新的串联反应合成重氮取代的二羰基化合物，然后利用重氮基团的多种特征反应，实现各种取代的异特窗酸和3-取代吡咯烷-2-酮类化合物的手性合成。

The chiral isotetronic acids and its nitrogen atom analogies (5-1H-pyrrol-2-ones)are regarded as privileged structural units in a large class of natural products and unnatural compounds. However, the catalytic methodology for the synthesis of chiral isotetronic acids and 5-1H-pyrrol-2-ones have still met with many formidable issues which continue to challenge the chemistry community. Owing to the importance for the discovery of new bioactive compounds, development of new efficient methods for asymmetric synthesis of spiro-isotetronic acid derivatives and 5-1H-pyrrol-2-ones is of high demand. In this project, two unprecedented asymmetric cascade reactions will be developed for facile synthesis of diazo substituted dicarbonyl compounds using b-diazo-a-ketone ester as nucliphile. After the follwing transformation of diazo functional group, kinds of substituted chiral isotetronic acids and 5-1H-pyrrol-2-ones will be prepared.