瘙痒是银屑病患者除皮疹外最常见的主诉症状。银屑病是T细胞介导的炎症免疫性疾病，肥大细胞是参与机体固有免疫应答的重要细胞，肥大细胞脱颗粒释放的细胞因子是致痒的重要因素，可促进T细胞及其它白细胞分泌细胞因子形成瘙痒循环。近年课题组围绕名医验方银屑灵复方开展体内外的临床和基础研究，发现其具有抑制角质细胞增殖、抗炎、止痒作用。本研究从中药防治银屑病瘙痒的视角出发，提出“银屑灵复方调控肥大细胞与Th1/Th2/Th17细胞因子交互效应可能是其改善银屑病性瘙痒的药效作用机制”这一假说。为验证其科学性，本项目运用网络药理学方法对复方成分与银屑病关键靶点筛选，再结合分子相互作用仪对筛选成分进行定量，将得到的潜在活性药物分别在小鼠和细胞模型上评价。课题的完成将为分子水平阐释中药防治银屑病瘙痒的物质基础及其调控机制提供更完善的理论依据，对验方的开发、推广及止痒药物的发现均有重要的意义。

Itching is the most common complaint symptom in psoriatic patients besides lesions. Psoriasis is an immune disease mediated by T cells. Mast cells are important in innate immune response. The cytokines released by mast cells are significant factors causing itching, which can promote the secretion of cytokines by T cells and other white blood cells. In recent years, our research group has carried out clinical and basic research in vivo and in vitro on the basis of the famous doctor's prescription, Yin-Xie-Ling formula, and we found that it has effects of inhibiting keratinocyte proliferation, anti-inflammatory and anti-pruritic. In this study, for treating psoriasis pruritus, it was proposed a hypothesis “Yin-Xie-Ling formula regulating mast cells and Th1/Th2/Th17 cytokines might be the pharmacological mechanism to reduce psoriatic pruritus”. To verify this hypothesis, we employ network pharmacology to screen the key components of psoriatic components, and use molecular interaction devices to quantitatively determine the components of the screening components. At last,the potential active drugs will be evaluated separately in mice and mast cell models. The complement of the project will provide a more theoretical basis for explaining the material basis and regulatory mechanisms of traditional chinese medicine in treating psoriatic pruritus, and also important for Yin-Xie-Ling formula development and antipruritic drugs discovery.