双酚A(BPA)对脑和行为发育的影响引起关注，但目前研究主要聚焦在出生前后暴露的作用。社会行为异常是自闭症等早期精神发育障碍的主要症状，青春期是社会行为形成关键期，此时性激素对相关神经环路功能成熟起激活作用。因此青春期暴露于弱雌激素活性的BPA可能影响社会行为形成，但目前对此缺乏认识。项目以整体动物研究青春期BPA暴露对早期社会行为(社会玩耍)的影响并导致成年后社会行为(社会互作、攻击、性行为等)改变；通过分析其神经信息流主要环节——社会认知识别和社会动机及相关脑区杏仁核的神经肽OT和AVP与中脑-边缘DA奖赏系统(VTA、NAc)、以及神经肽对DA信号的作用研究BPA影响社会行为的神经机制；再用Dil荧光散射和电生理技术借助特异性工具药分析离体脑片NAc区神经元树突棘形态和场电位长时程增强(LTP)，从形态和功能确认BPA影响社会行为的关键脑区及其信号通路，揭示BPA影响社会行为发育机制

The study of the influence of bisphenol-A (BPA) on the development of brain and behavior focused currently on the effects of perinatal exposure of BPA on adult behavior, especially the cognition and emotion. Social behavior is necessary for animal survival and reproduction. Adolescence is critical period of social behavior formation, in which time gonadal hormones activate the neural circuits and function related to behavior. Thus we speculate that adolescent exposed to BPA, a environmental compound with weak estrogen activity, may influence the formation of social behavior; however little is known about this. The present project aims to study the effects of early pubertal exposure to BPA on social behavior (especially social play) and even enduring influence on social behavior adulthood, including social interactions, aggressive behavior, sexual behaviour, etc. In order to investigate the mechanism underlying BPA-induced changes in social behavior, the main neural links of social information, such as neuropeptides AVP and OT of amygdala (MeA) and DA signal system of limbic system-midbrain (VTA, NAc), which are related to social cognition, motivation and reward, are analyzed. Furthermore, to confirm the critical brain regions of BPA influence social behavior, the morphologic change of dendritic spines of brain area NAc is observed with Dil fluorescent scattering technology and field potential long-term potentiation (LTP) of NAc is detected with electrophysiological technology in vitro. Finally the signaling pathways through which BPA affects social behavior are analyzed using specific agonists and antagonists of receptors to reveal the molecular mechanisms of adolescent BPA exposure affecting social behavior development.