水稻瘤矮病毒（RGDV）由电光叶蝉以雄虫精子介导的父性传播为主、雌虫经卵的母性传播为辅的方式传至后代。RGDV对雄虫及通过父性传播至后代的虫卵无显著不利，但对雌虫及通过母性传播至后代的虫卵不利影响较大。推测病毒母性经卵传播时在卵巢组织中大量增殖，诱导过度的细胞凋亡，导致后代虫卵发育衰败，而父性精子介导的病毒传播不存在这个影响。本项目将从病毒诱导细胞凋亡角度，深入解析RGDV诱导雌虫卵巢的细胞凋亡在促进病毒增殖及导致雌虫生殖力衰退中的作用机制，探讨RGDV通过母性和父性垂直传播的后代虫卵发生细胞凋亡与病毒增殖及虫卵发育的相关性，揭示母性传播的病毒诱导的虫卵细胞凋亡导致虫卵发育衰败，而父性经精子介导传播的病毒则不造成类似影响。研究结果将阐明介体细胞凋亡调控病毒以雄虫精子介导为主、雌虫经卵为辅的垂直传播的内在机制。

Rice gall dwarf virus (RGDV) is vertically transmitted by leafhopper Recilia dorsalis in the dominantly paternal transmission and supplementally maternal transmission to offspring. The paternally transmitted RGDV has no significant effect on the fitness of male and offspring, while the maternally transmitted RGDV has disadvantage for female and the eggs of offspring. We hypothesized that in the process of maternal transmission, viral multiplication in ovaries induced excessive apoptosis, leading to the decay of eggs development, but this effect of virus was absent in the process of maternal transmission. In this project, from the perspective of virus inducing apoptosis, we will investigate the mechanism underlying RGDV induces apoptosis in female ovaries for facilitating viral multiplication and causing degeneration of female reproduction. We will also discuss the association of apoptosis occurring in eggs from maternal and paternal transmission with viral multiplication and eggs development. It will be revealed that apoptosis of eggs induced by RGDV in maternal transmission causes the decay of eggs development, while the virus in paternal transmission could not have the similar effect on eggs. The results will uncover the mechanism by which apoptosis of insect vector regulates RGDV vertical transmission of dominant paternal transmission and supplemental maternal transmission.