稀有事件作为随机多尺度动力系统研究的最典型问题之一，广泛出现于统计物理、材料科学、流体力学以及生命科学中。本项目在前期基于金属熔化的微观机理、管槽流从层流到湍流转变的相变机制以及系统生物学中稀有事件取得重要进展的基础上，通过整合分子动力学和计算流体相关研究人员，集成当今稀有事件模拟领域最尖端算法和理论用于研究冰融化的微观机理、三维管槽流的稳定性以及λ噬菌体溶原溶菌状态转变过程分析。本项目为前期研究工作的自然延续与集成，致力于解决科学前沿的稀有事件问题，具有重要的实际意义和理论价值。

Rare event is one of the most challenging multi-scale problems among stochastic dynamical systems. It widely appears in statistical physics, materials science, fluid mechanics and life sciences. Based on the important progress achieved in studying the microscopic melting mechanisms of a metal, the phase transition interpretation of the onset of turbulence and rare events in systems biology, we integrate active researchers in molecular simulations and computational fluid dynamics and top algorithms in rare event study to investigate the microscopic mechanisms of ice melting, statistical mechanics understanding of the hydrodynamic instability and the lysis-lysogeny transition analysis of Lambda-phage infected E. Coli. This is a natural continuation of our previous project. The aim of the current project is to solve some fundamental problems in frontiers of science with our developed algorithms and theory, which has both practical and theoretical importance.