石墨烯基超灵敏呼气一氧化氮传感复合材料及芯片研究

研究制备超灵敏呼气一氧化氮（NO）传感材料及芯片在呼吸系统疾病诊断预防领域具有极其重要的意义。本申请基于团队前期工作基础，拟开展研究有：（1）通过NO特异响应性客体分子与石墨烯主体进行超分子组装，借助冻干技术制备微观结构可调控的超灵敏NO微纳复合材料。（2）利用喷墨打印技术和对石墨烯基复合材料的亲水性调节，实现对气敏材料的喷墨打印及其微型NO呼气传感芯片的一体化制备。（3）采用对比评价对所得材料和芯片性能进行测试与研究。本项目从基础研究的角度出发，重点对获得的石墨烯基气敏材料微观结构与宏观气体传感性能间的联系、复合材料与气体分子间的选择性相互作用机理等规律性问题进行分析和总结，探究材料的气体传感机制等基本科学问题，建立材料和芯片优化理论，为高性能NO呼气传感芯片的产业化应用提供理论基础和实验依据。

Fractional exhaled nitric oxide (FeNO) is the significant criterion for respiratory disease diagnosis and prevention. Therefore, the nitric oxide (NO) ultrasensitive material and its sensing chip have attracted attentions of researchers. Based on our previous works, three aspects were proposed in this proposal: (1) A series of graphene-based micro-nano composites featuring with NO ultrasensitivity will be designed and prepared via supramolecular assembly between NO-responsive guest molecules and host graphene. Combing with lyophilization, the composites with different nanostructures such as nanoscroll, hollow nanosphere and interpenetrating aerogel, are expected for precise NO detection. (2) Once managed to be hydrophilic enough, the obtained graphene-based composite will be ink-jet printed on the interdigital electrode (IE) to achieve the integrated fabrication of exhaled NO-sensing chips. (3) The measurement of gas sensing properties and comparison experiments will be performed for systemic evaluation on the performance of the as-prepared NO sensing materials and chips. From the perspective of fundamental researches, our work is going to focus on the relationship between microstructures and NO-sensitivities of the graphene-based gas sensing materials, along with the selective interaction mechanism among molecules of gas and composite materials. The gas sensing mechanism and the corresponding optimization theory will be ultimately explored, which is expected to be certainly beneficial for commercialization of exhaled NO-sensing chips in clinical application.