基于单宁酸-环形PEtOx刷的多层级结构构建血液透析膜仿生表面及其氧化应激干预效果评价

批准号:
51973158
项目类别:
面上项目
资助金额:
64.0 万元
负责人:
陈莉
依托单位:
学科分类:
其他有机高分子功能材料
结题年份:
2023
批准年份:
2019
项目状态:
已结题
项目参与者:
陈莉
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中文摘要
氧化应激是血液透析患者并发心血管疾病的重要病理生理基础,严重影响着患者预后效果及远期生存率。本项目以干预血液透析患者的氧化应激状态为目标,提出对血液透析膜表面进行多层级结构构建,在分子水平进行仿生功能化设计。利用单宁酸抗氧化能力和粘附能力,在透析膜表面构建单宁酸涂层,探讨单宁酸对活性氧自由基、氧化应激产物和靶器官等不同研究层面的氧化应激干预效果,厘清透析膜与氧化应激水平之间的作用规律;进一步利用环形PEtOx刷和类肝素聚合物在透析膜表面构建类天然血管壁的仿生表面拓扑结构,研究单宁酸-环形PEtOx刷的表/界面结构对透析膜血液相容性的影响,提高透析膜的抗凝血性能和生物相容性。通过分子设计和表面拓扑结构调控,揭示氧化应激干预-仿生表面拓扑结构-血液透析膜性能之间的相互关系,优化血液透析膜各项性能,制备满足临床需求的高性能血液透析膜,为血液透析膜的设计和制备提供系统全面的理论支撑和实践依据。
英文摘要
For cardiovascular disease of hemodialysis patients, oxidative stress is a vital pathophysiological basis and severely impacts the prognosis and long-term survival rate. Herein, the proposal aims to intervene in the oxidative stress state of hemodialysis patients which based on the molecular-level bionic functional design to construct The tannic acid (TA)-poly(2-ethly-2-oxazoline) (PEtOx) brush hierarchical structure on the hemodialysis membrane surface. We are primarily focusing on the evaluation of oxidative stress intervention from different levels on the reactive oxide species, blood, oxidative stress products and target organ, and to clarify mechanism between hemodialysis membrane and oxidative stress level based on the incorporation of anti-oxidative and adhesive TA coating. Further, to elucidate the effect of the surface/interface structure of TA-cyclic PEtOx brush on the hemodialysis of dialysis membranes and improve anticoagulation property and biocompatibility during the hemodialysis, a biomimetic surface topology morphology of the natural blood vessel walls is constructed out of a biocompatible cyclic PEtOx brush and a heparin-mimicking polymer on the hemodialysis membrane surface. This project through molecular design and regulation of surface topology morphology reveal the interrelation among intervention of oxidative stress-surface topology morphology-hemodialysis membrane performance and prepare high-performance hemodialysis membranes to pursue clinical needs via optimize the performance of hemodialysis membranes. Meanwhile, this project will provide systematic and comprehensive theoretical support and practical basis for the design and development of hemodialysis membranes which can significantly relieve the oxidative stress state of patients with renal failure.
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DOI:10.1021/acsami.0c13382
发表时间:2020-11-18
期刊:ACS APPLIED MATERIALS & INTERFACES
影响因子:9.5
作者:He, Yang;Chen, Qi;Chen, Li
通讯作者:Chen, Li
DOI:10.1016/j.memsci.2020.118896
发表时间:2021-01-02
期刊:JOURNAL OF MEMBRANE SCIENCE
影响因子:9.5
作者:Chen, Qi;He, Yang;Chen, Li
通讯作者:Chen, Li
DOI:10.1021/acs.biomac.3c00298
发表时间:2023-06
期刊:Biomacromolecules
影响因子:6.2
作者:Songlin Xing;Qiqi Wang;Yang He;L. Chen
通讯作者:Songlin Xing;Qiqi Wang;Yang He;L. Chen
DOI:10.1016/j.memsci.2021.119174
发表时间:2021-02-18
期刊:JOURNAL OF MEMBRANE SCIENCE
影响因子:9.5
作者:Chen,Qi;He,Yang;Chen,Li
通讯作者:Chen,Li
DOI:10.1021/acsami.0c07090
发表时间:2020-08-19
期刊:ACS APPLIED MATERIALS & INTERFACES
影响因子:9.5
作者:Jiang,Peng;He,Yang;Chen,Li
通讯作者:Chen,Li
国内基金
海外基金
