骨组织再生与代谢稳态受多种信号因子精确的协作调控，发掘并研究关键转录因子在颌面部骨组织再生和代谢稳态调控中的作用是当前的研究热点。本课题组在充分总结和分析当前国内外研究进展，并结合一系列前期试验结果的基础上，推测FOXC2在颌面部骨组织再生和甲状旁腺激素响应过程中可能发挥重要的调控作用。本项目拟通过构建FOXC2基因敲减/过表达细胞株，结合一系列分子生物学实验，并利用裸鼠皮下异位成骨模型、大鼠牙槽骨临界缺损模型以及OVX大鼠模型，从体外细胞实验与动物体内实验两个层面探讨FOXC2在颌面部骨组织再生和甲状旁腺激素响应过程中的调控作用及其机制。本研究的开展将有助于揭示和完善颌面部骨组织代谢调控的系统机制，并可能为颌骨组织缺损与骨质疏松类疾病的预防和治疗提供新的思路和理论依据。

The bone tissue regeneration and homeostasis are cooperatively regulated by multiple signaling factors. The role and mechanism of key transcription factors in maxillofacial bone tissue regeneration and homeostasis emerges as one of the hot research fields. Based on our analysis of the current research progress at home and abroad, and a series of previous experimental results, we speculated that FOXC2 might play an important role in the process of maxillofacial bone tissue regeneration and parathyroid hormone response. This project aims to create novel FOXC2 knock-down and over-expression cell lines, and perform a series of molecular biological experiments to take sights on the role of FOXC2 in bone regeneration and homeostasis. The subcutaneous ectopic osteogenesis model, critical sized rat alveolar bone defect model and OVX rat model will also be utilized to further explore the effect and mechanism of FOXC2 in maxillofacial bone tissue regeneration and parathyroid hormone response. This project will be helpful to reveal the systemic mechanism of maxillofacial bone tissue metabolism, and may provide new ideas and theoretical basis for the prevention and treatment of osteoporosis and bone tissue defects.