钙结合蛋白S100A11是S100家族重要成员之一，其可根据外部的环境条件和细胞类型不同分布于胞膜、胞浆及胞核中，起到不同的调控作用。当S100A11由胞浆转入胞核时可以抑制DNA合成，阻滞细胞增殖。我们前期发现鼻息肉中上皮干细胞异常增殖明显，与上皮重塑密切相关。同时我们发现鼻息肉中S100A11蛋白表达上调，定位由正常上皮干细胞的胞浆转移至胞浆及胞核同时表达，且以胞核为主。因此，我们推测鼻息肉上皮干细胞中S100A11蛋白的异常定位和表达可能与上皮干细胞的异常增殖相关。为了验证这一科学假说，我们拟进行以下研究：（1）观察鼻上皮干细胞处于不同细胞周期时S100A11核浆穿梭效应的特点（2）S100A11不同定位对鼻上皮干细胞增殖能力的调控效应（3）S100A11不同定位调控鼻上皮干细胞增殖的具体机制。为阐明鼻息肉上皮干细胞异常增殖发生的分子机制，探索新的治疗靶点提供途径。

The calcium binding protein S100A11 is one of the important members of the S100 family, which can play different regulatory roles and distributed in the cytoplasm, cytoplasm and nucleus depending on the external environmental conditions and cell types. When S100A11 is transferred from the cytoplasm to the nucleus, it can inhibit DNA synthesis and block cell proliferation.We found that the abnormal proliferation of epithelial stem cells in nasal polyps was closely related to epithelial remodeling. At the same time, we found that the expression of S100A11 protein in nasal polyps was up-regulated, and it was localized by the cytoplasm of normal epithelial stem cells to the cytoplasm and nucleus, and was mainly cytoplasmic. Therefore, we hypothesized that abnormal localization and expression of S100A11 protein in nasal polyp epithelial stem cells may be related to abnormal proliferation of epithelial stem cells. In order to verify the scientific hypothesis, we proposed the following research: (1) to observe the characteristic of S100A11 nucleoplasm shuttle effect of nasal epithelium stem cells in a different cell cycle (2) to illuminate the proliferation effect of different S100A11 positioning control in nasal epithelium stem cells (3) the mechanism of S100A11 positioning control nasal epithelium stem cells proliferation.To elucidate the molecular mechanism of abnormal proliferation of nasal polyp epithelial stem cells and explore new therapeutic targets.