颗粒物污染是目前最突出的环境问题，它的毒性主要与其中的有机物相关，然而对雾霾天气如何驱动有机物尤其是高毒性有机物的大气环境行为变化并影响其呼吸暴露风险尚缺乏系统深入的认知。本项目拟以色质联用为平台，结合实验室模拟以及外场观测，对高活性有机物大气转化通路进行构建，探究气态污染物、颗粒物以及海滨环境对其影响；对不同活性、不同地理源高毒性有机物及其产物进行持续监测，以统计分析及模型构建为手段，分析其气粒分配、粒径分布、迁移转化等环境行为，确定雾霾天气的发生对典型高毒性有机物环境过程的作用机制，为雾霾天气下有机物的演化及颗粒物毒性研究提供参考数据。

Particulate matter poses a serious threat to the ecosystem and human health, characterized by the sequent occurrence of lasting haze events. The toxic effects of particulate matter are usually related to the organic part. However, there is still a lack of systematic understanding of the mechanism underlying how haze weather drives the evolution of atmospheric organic compound, especially organic substances with high toxicity and posed high risk of exposure through respiratory. This project intends to reconstruct the major reaction of the organic compound with high-activity and high-toxicity, combining the laboratory experiment and field observation, based on use a technology platform using chromatography with mass spectrometry. The influence of different levels of gaseous pollutants, particulate matter and the coastal environment on the atmospheric oxidation of organic compounds was detailedly studied; Simultaneous observation of highly toxic organic substances with different activity and different geographic origin and their oxidation product will be conducted. By the combination of statistical analysis and model construction, every environmental processes compartment will be studied to determine the influence of occurrence of haze weather on the evolution process of the typical organic pollutants with high toxicity. This project provides basic data for the mechanism underlying how haze weather drive the evolution of majority organic compound.