宿主肠道产生的活性氧（ROS）能够直接损伤细菌DNA，蛋白质和脂类，有效抵抗病原菌侵犯。NADH过氧化物酶Ahp系统是细菌清除微量H2O2的重要蛋白。我们前期研究发现肠道致病菌假结核耶尔森氏菌（Yersinia pseudotuberculosis）缺少Ahp系统的同源蛋白。基于此，本项目拟开展三个方面的研究：1）鉴定Ahp的替代蛋白；2）揭示该替代蛋白的生物学功能；3）探究该替代蛋白的表达调控机制。此项研究将阐明Y. pseudotuberculosis非典型Ahp系统的功能及调控机制，揭示细菌对相似环境的不同适应方式，为相关细菌感染的防治提供理论基础。

ROS produced by host intestine could effectively resist pathogen invasion by damaging DNA, protein and lipids. NADH peroxidase (Ahp) is the primary scavenger of trace hydrogen peroxide in many bacteria. Our previous results showed that enteric pathogen Yersinia pseudotuberculosis lacked Ahp homologue. Based on that, this study aims to identify protein that possesses the function of Ahp, figure out its physiological role and regulation pattern in Y. pseudotuberculosis. This study will elucidate the function and regulatory mechanism of the atypical Ahp system, confirm the biological significance in environmental adaption and provide theoretical instructions for the treatment of associated bacterial infections.