填充萃取剂固相微萃取（MEPS）是一种基于固相萃取原理的新型样品前处理技术，其萃取效率的高低与萃取剂的性质密切相关。商品化填充型萃取剂抗杂质干扰性能差、使用寿命低，对极性、亲水性物质萃取效率也有限，难以满足药物残留检测灵敏度高、准确度好、实用强的要求。本项目拟借助离子液体性质可调控和石墨烯萃取容量高等优点，根据分析物的分子结构设计合成相应的离子液体单体，通过绿色环保的前线聚合反应制备聚合离子液体-氧化石墨烯整体柱，发展基于整体柱的MEPS方法，在提高萃取效率的同时改善MEPS萃取剂对复杂基质样品的实用性和使用寿命。以高效液相色谱为分析手段，对芳基丙酸类、诺氟喹酮类等常见药物残留建立分析方法，对环境中相关污染物的含量水平进行考察。本项目将通过整体柱技术来弥补现有MEPS萃取剂在应用中的各种不足，并采用从分析物化学结构出发设计新型萃取剂的方法，针对性地解决难萃取药物残留的分析检测问题。

Microextraction by packed sorbent (MEPS) is a novel efficient sample preparation method based on extraction mechanism of solid-phase extraction (SPE). Extraction efficiency of MEPS is directly related to the performance of sorbent materials. Commercialized available sorbents exhibit limited resistance to impurities and low extraction capacity for polar and hydrophilic compounds represented by chemical drugs. In this project, polymeric ionic liquids-graphene oxide composite monolith will be prepared by a green frontal polymerization method, and used as MEPS sorbent materials for the determination of drug residues such as aryl propionic acid and fluroquinolones derivatives in environmental samples, coupled to high performance liquid chromatography. To strengthen the interaction between sorbent and analytes, ionic liquids monomers will be functionalized according to the molecular structures of drug analytes. Drawbacks of commercial packed sorbent will be overcome by monolith materials, and the strategy of designing sorbent material based on property of analytes will also create more efficient analytical methods of intractable drug residues.