聚合物囊泡在外场下的稳定性和形变动力学

聚合物囊泡因其特殊的结构与性质可应用于开发纳米反应器、靶向药物输运、基因注射等技术，因此在生物、医药、纳米科学等领域正发挥着越来越重要的作用。近年来对于嵌段共聚物囊泡的研究大多集中在囊泡的制备以及目标囊泡性质的可控化上，而在囊泡的稳定性与形变上的研究却少有涉及。对囊泡的形变及其稳定性的研究有利于人类理解囊泡的运输调控机制。本项目以囊泡为模型，利用自洽场理论和耗散粒子动力学方法研究流场驱动以及管道受限对聚合物囊泡的稳定性与形变的影响，得到囊泡形变、愈合以及失稳的动力学机制，并进一步研究囊泡携带纳米粒子情况下的动力学行为，为囊泡在药物输运、基因注射等领域的应用提供非常重要的指导。

Polymer vesicles possess great significance on the realms of biology, medicine, and nano-science for its potential application in developing advanced technologies like nano reactor, drug targeting delivery and gene therapy because of their special structure. The majority of studies in recent decades have been focused on the preparation of vesicles and controlling the properties of targeted vesicles, while the research on the stability and deformation of vesicles is seldom. It is very helpful for human to understand the mechanism of vesicle transportation. In this project, we use the polymer vesicles in the nanotube under the field as a model to study the effects of the fluid and the confinement on the stability and the deformation of polymer vesicles by self-consistent field theory and dissipative particle dynamics method, then obtain the mechanism of the deformation, coalescence and unstability of vesicles. The vesicles with nanoparticles will also be considered. The research can provide the important direction in the fields of medicine transportation and gene injection.