替代针灸传统穴位埋植材料的可注射长效原位凝胶系统及相关作用比较研究

中医针灸传统穴位埋线疗法所用的材料仅限于羊肠线，羊肠线主要用于外科缝合，并非特制的埋植专用线，不能完全满足临床要求,如羊肠线可吸收性差，组织反应和易感染，植入时疼痛，在体内的吸收速度和刺激强度难于控制等。因此，寻找具有可控性和可生物降解的新型埋植系统就显得极为重要，也是该方法发展创新的需要。支气管哮喘（哮喘）是全球最常见的慢性疾病之一。目前，西医尚缺乏持久有效的根治方法。穴位埋线疗法是临床应用比较广泛的治疗支气管哮喘的方法。本课题拟采用可生物降解聚合物聚乳酸－羟基乙酸共聚物（PLGA）作为主要载体材料，以细辛脑为模型药物，制成可注射长效原位凝胶，通过比较两种埋植材料对模型疾病哮喘的药效、作用机理、局部生理生化的变化，研究在体内可控制释放、生物相容性好、可生物降解的穴位植入原位凝胶，以替代羊肠线，旨在为穴位埋藏疗法提供一种新的埋植系统，同时也为中药缓控释制剂的研究开创一个新的方向。

The material of Catgut embedding of traditional Chinese medicine acupuncture is only catgut. The catgut is mainly used for surgical suture and is not a special embedding string. It can't fully satisfy the clinical requirements. For example, it has bad absorbability, histological reactions and is easy to cause Infection, Implanted pain and hard to control the absorption rate and stimulation intensity in vivo, etc. Therefore it is distinctly important to find a new embeddable system which is controlled and biodegradable. It is also the need of Development Innovation. Bronchial asthma is one of the most common chronic diseases in the world. Western medicine is still lack of the lasting effective cure method at the moment. Acupoint thread-embedding therapy is the treatment method of bronchial asthma in widely clinical application. This project adopts biodegradable polylactic-co-glycolic acid (PLGA) as the main carrier material. It manufactures a system injectable and long-term effective in situ gel based on asarone as model drug. According to compare these two implantable materials' drugaction to model disease asthma, mechanism of action and local physiological and biochemical changes, it researches the in situ gel of acupoint thread-embedding which is good at controlling the release of drug, biocompatibility and biodegradation to replace catgut in order to provide a new embeddable system for acupoint thread-embedding therapy, meanwhile, create a new way for the research of Chinese sustained and controlled release preparations.