具有中医特色的付罐经皮给药物理促渗新技术的系统研究

已完成的两个国家自然科学基金课题研究表明，付罐处理后药物透皮吸收率和治疗效果显著提高，为付罐疗法作为物理促渗新技术的系统研究奠定了基础。项目拟通过筛选适合的模型药物、动物模型，借助CLSM、UPLC-MS/MS、荧光标记、电子显微、DSC、ERS、X-射线衍射等分析技术和手段，建立科学合理经皮给药检测评价方法，在宏观效果和微观结构两个方面，从局部和全身作用上全面系统的研究付罐疗法对经皮给药产生促渗影响因素和作用、作用机制、透皮促渗途径及促渗的效果；探讨和比较已有物理促渗技术如超声、离子导入技术及化学促渗剂与付罐促渗技术对中药复方和大分子药物经皮给药的促渗作用；全面研究付罐疗法作为经皮给药物理促渗新技术对模型药物的体内外相关试验，建立该新型物理促渗技术的药动学和药效学主要参数。为开发具有中医特色、方便实用的新型物理促渗新技术的推广和应用提供科学依据。

Two previously completed national natural science foundations of topic research showed that the drug transdermal absorption rate and treatment effect was significantly improved after Fu's cupping, which laid the foundation for the further study of physical penetration technology. The project ,through choosing suitable model drugs and animal models, and with the help of analytical methods and techniques ,such as CLSM,UPLC – MS/MS, fluorescent tags, electron microscopy, DSC, ERS, X-ray diffraction, establishing the scientific and reasonable detection methods. The research is aimed to study Fu's cupping therapy for both local and systemic effect,for which to describe the penetration factors and actions, mechanism, percutaneous permeation pathway and effect of penetration behind the transdermal drug delivery, in the two aspects of macro effect and micro structure study; also to compare the existing physical penetration techniques, such as ultrasound,iontophoresis technology and chemical peneration enhancers,with Fu’s cupping,considering the peneration effects for Chinese herbal compound and macromolecular drugs .This comprehensive study of Fu's cupping therapy will be a new transdermal delivery physical penetration technology to test model agents's in vitro and in vivo correlation and establish the main parameters of pharmacokinetics and pharmacodynamics . Fu’s cupping can provide the scientific basis for the development and application of a new physical penetration enhancement technology , which has its own Chinese characteristics.