机体正常的免疫应答对于维持机体内环境的稳定以及抵御外来物质的侵染都有着重要的作用。本实验室前期发现了一种乙肝表面抗原结合蛋白（HBsAg Binding Protein，SBP），初步研究表明SBP能够与多种病毒抗原具有高度亲和作用，亲和常数高达500万，其能够介导树突状细胞吞噬抗原，并能显著提高疫苗抗原在动物体内免疫抗体的效价，具有非常显著的促进免疫应答和免疫调控作用，然而SBP调控免疫应答的具体分子机制尚不清楚。 本课题拟在前期研究的基础上，通过生物信息学手段和蛋白互作等研究方法，希望能够找到SBP与众多病毒结合的位点和结构特征，并试图发现细胞表面的SBP受体和SBP在细胞内产生的相关信号通路，阐明SBP作用的分子机制。通过本课题的研究能够揭示SBP促进机体对多种病毒抗原产生较强免疫应答的原因，有助于加深人们对病毒感染与免疫应答过程的认识，同时也有利于开发出新一代的高效疫苗佐剂。

The normal immune responses in the body play a important role in maintaining the stability of internal environment and protecting foreign substances from entering our bodies. The imbalance of immune responses would cause many diseases. SBP( HBsAg Binding Protein ) is a protein founded by our lab, and it can interact with many antigens of viruses, promote DC cells to phagocytose antigens and improve the immune responses in animals. But the mechanisms of SBP is still not clear. We want to find the interaction site between SBP and viruses, discover the receptors of SBP and work out relative signal pathways of SBP by using bioinformatics methods and protein interaction experiments. The final goal is to find out the mechanisms of SBP. This project could show the reason that why SBP can improve the immune responses, help people know the process of virus infection and immunity and help to develop the new generation of highly-effective vaccines.